{"id":210583,"date":"2022-06-23T08:30:16","date_gmt":"2022-06-23T08:30:16","guid":{"rendered":"https:\/\/www.clarivate.com.cn\/?p=210583"},"modified":"2026-03-12T08:47:50","modified_gmt":"2026-03-12T08:47:50","slug":"antibody-drug-conjugates-and-bispecifics-seize-the-spotlight-at-asco-2022","status":"publish","type":"post","link":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/blog\/antibody-drug-conjugates-and-bispecifics-seize-the-spotlight-at-asco-2022\/","title":{"rendered":"2022\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0aADC\u548c\u53cc\u6297\u6210\u4e3a\u7126\u70b9"},"content":{"rendered":"

\u4e3a\u4e86\u786e\u5b9a\u672c\u5e74\u5ea6\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b\u5185\u5bb9\uff0c\u79d1\u777f\u552f\u5b89\u80bf\u7624\u5b66\u4e13\u5bb6\u56e2\u961f\u4ed4\u7ec6\u7814\u7a76\u4e86\u4eca\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u53d1\u5e03\u7684\u6570\u5343\u7bc7\u6587\u732e\u6458\u8981\u3002\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u4e2a\u660e\u663e\u8d8b\u52bf\uff1a\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08<\/strong>ADC<\/strong>\uff09\u548c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7b49\u521b\u65b0\u7597\u6cd5\u6210\u4e3a\u5173\u6ce8\u7126\u70b9\u3002<\/strong><\/p>\n

\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u548c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5e76\u4e0d\u662f\u65b0\u578b\u836f\u7269\u3002\u5728\u8fc7\u53bb\u4e8c\u5341\u591a\u5e74\u91cc\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u5df2\u7ecf\u6279\u51c6\u4e86\u5341\u51e0\u79cd\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u4ee5\u53ca\u4e09\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7528\u4e8e\u80bf\u7624\u9002\u5e94\u75c7\u3002\u5728\u8fc7\u53bb\u4e09\u5e74\u91cc\uff0c\u6279\u51c6\u7684\u901f\u5ea6\u660e\u663e\u52a0\u5feb\u3002<\/p>\n

\u73b0\u5728\uff0c\u5404\u5927\u836f\u4f01\u4e89\u76f8\u5f00\u53d1\u6b64\u7c7b\u5019\u9009\u836f\u54c1\uff0c\u5168\u529b\u63a8\u8fdb\u8fd9\u4e9b\u521b\u65b0\u7597\u6cd5\uff0c\u4ee5\u6539\u5584\u80bf\u7624\u60a3\u8005\u7ed3\u5c40\u3002\u4f8b\u5982\uff0c\u7b2c\u4e00\u4e09\u5171\u548c\u963f\u65af\u5229\u5eb7\u6b63\u5728\u4f7f\u7528\u8054\u5408\u5f00\u53d1\u7684 ADC \u836f\u7269 ENHERTU \u7684 3 \u671f\u8bd5\u9a8c\u7ed3\u679c\u7ee7\u7eed\u81f4\u529b\u4e8e\u6269\u5927 HER2 \u9776\u5411\u6cbb\u7597\u8303\u56f4\uff0c\u4ee5\u6cbb\u7597 HER2 \u4f4e\u8868\u8fbe\u60a3\u8005\u3002\u8be5 DESTINY BREAST03 \u8bd5\u9a8c\u53ef\u80fd\u4f1a\u91cd\u65b0\u754c\u5b9a\u4e73\u817a\u764c\u7684\u5206\u7c7b<\/a>\u3002<\/p>\n

\u5f53\u7136\uff0cADC \u548c\u53cc\u6297\u5e76\u4e0d\u662f\u4eca\u5e74\u4f1a\u8bae\u4e0a\u5d2d\u9732\u950b\u8292\u7684\u552f\u4e00\u6cbb\u7597\u65b9\u6cd5\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e00\u9879\u9488\u5bf9\u65e7\u5f0f\u6297 PD-1 \u5355\u514b\u9686\u6297\u4f53 dostarlimab\uff08Jemperli\uff09\u7684\u6781\u5c0f\u578b\u8bd5\u9a8c\u5360\u636e\u4e86\u7279\u522b\u62a5\u9053\u5916\u7684\u5927\u591a\u6570\u5934\u6761\u3002\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u6797\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u62a5\u544a\u79f0<\/a>\uff0c\u5728\u4e00\u9879 2 \u671f\u7814\u7a76\u4e2d\uff0c14 \u540d\u76f4\u80a0\u764c\u60a3\u8005\u5747\u5b8c\u5168\u7f13\u89e3\u3002\u8fd9\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u5e0c\u671b\uff1a\u6216\u8bb8\u6709\u4e00\u5929\uff0c\u5728\u4e0d\u8fdb\u884c\u624b\u672f\u3001\u5316\u7597\u548c\u653e\u7597\u7684\u60c5\u51b5\u4e0b\u4ec5\u9760\u514d\u75ab\u7597\u6cd5\u5c31\u8db3\u4ee5\u6cbb\u7597\u67d0\u4e9b\u764c\u75c7\u3002<\/p>\n

Jemperli \u7531\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u5f00\u53d1\uff0c\u81ea 2021 \u5e74 4 \u6708\u5f00\u59cb\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\u548c\u67d0\u4e9b\u5b9e\u4f53\u7624\u3002\u8be5\u836f\u7269\u901a\u8fc7\u9776\u5411\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08\u4e00\u79cd\u5728 25-30% \u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u4e2d\u53ef\u89c1<\/a>\u7684\u751f\u7269\u6807\u5fd7\u7269\uff09\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

\u6b63\u5982\u6211\u4eec\u5728\u4eca\u5e74 ASCO \u5e74\u4f1a\u4e0a\u53d1\u5e03\u7684\u5173\u952e\u8fdb\u5c55\u62a5\u544a\u4e2d\u5f3a\u8c03<\/a>\u7684\u90a3\u6837\uff0c\u83b7\u6279\u836f\u54c1\u60a3\u8005\u7fa4\u4f53\u7684\u6570\u636e\u5448\u73b0\u53cd\u590d\u6027\u7279\u5f81\u3002\u8fd9\u663e\u793a\u4e86\u5728\u73b0\u6709\u7684\u5e02\u573a\u73af\u5883\u548c\u590d\u6742\u7684\u80bf\u7624\u6cbb\u7597\u6a21\u5f0f\u4e2d\u8fd9\u4e9b\u4e0a\u5e02\u836f\u7269\u8fd8\u5177\u6709\u4e0d\u65ad\u589e\u957f\u7684\u6f5c\u529b\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u4eba\u4e0d\u4ec5\u4ec5\u5728\u5173\u6ce8\u65b0\u7597\u6cd5\uff0c\u4e5f\u5728\u63a2\u7a76\u5982\u4f55\u6700\u597d\u5730\u5229\u7528\u73b0\u6709\u7597\u6cd5\u3002<\/p>\n

ASCO 2022\u00a0<\/strong>\u5168\u7403\u5341\u5927\u5173\u952e\u4eae\u70b9<\/strong><\/h3>\n
    \n
  1. \u91cd\u5927\u7a81\u7834\uff01ENHERTU \u4f7f HER2 \u4f4e\u8868\u8fbe\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u83b7\u5f97\u524d\u6240\u672a\u6709\u7684\u751f\u5b58\u7ed3\u5c40<\/li>\n
  2. \u62d3\u8fbe\u7ef4\u00ae\u5728\u6cbb\u7597\u96be\u6cbb\u6027 HR+\/HER2- \u8f6c\u79fb\u6027\u4e73\u817a\u764c\u65f6\u8fbe\u5230\u5176\u4e3b\u8981\u7ec8\u70b9\uff08\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff09<\/li>\n
  3. Rubraca \u5c06\u6210\u4e3a\u7b2c\u4e09\u79cd\u7528\u4e8e\u665a\u671f\u5375\u5de2\u764c\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684 PARP \u6291\u5236\u5242<\/li>\n
  4. \u7f57\u6c0f\u7684\u6297 TIGIT \u836f\u7269 Tiragolumab \u5728\u672a\u7ecf\u6cbb\u7597\u7684\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u65b9\u5411\u4e0a\u5931\u8d25<\/li>\n
  5. \u5b89\u9002\u5229\u00ae\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u7ee7\u7eed\u6539\u5584\u665a\u671f\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f<\/li>\n
  6. IMBRUVICA \u8054\u5408\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u53ef\u5ef6\u7f13\u65b0\u786e\u8bca\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u8001\u5e74\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55<\/li>\n
  7. \u53cc\u7279\u5f02\u6027\u6297\u4f53 Glofitamab \u6cbb\u7597\u96be\u6cbb\u6027\u5f25\u6f2b\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e34\u5e8a\u7597\u6548\u663e\u8457<\/li>\n
  8. \u53cc\u7279\u5f02\u6027\u6297\u4f53\u5728\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6d3b\u6027<\/li>\n
  9. Mirati \u7684 KRAS \u6291\u5236\u5242 Adagrasib \u5bf9\u65e2\u5f80\u6cbb\u7597\u8fc7\u7684 KRAS G12C \u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6709\u6548<\/li>\n
  10. Favezelimab\uff08\u6297 LAG-3\uff09\u8054\u5408\u53ef\u745e\u8fbe\u00ae\uff08\u6297 PD-1\uff09\u5bf9\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u6709\u6297\u80bf\u7624\u6d3b\u6027<\/li>\n<\/ol>\n

    ASCO 2022\u00a0<\/strong>\u4e2d\u56fd\u5927\u9646\u5730\u533a\u4e94\u5927\u5173\u952e\u4eae\u70b9<\/strong><\/p>\n

      \n
    1. CT-041 \u6709\u671b\u6210\u4e3a claudin18.2 \u9633\u6027\u665a\u671f\u80c3\u764c\u548c\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8 (GEJ) \u764c\u7684\u6f5c\u5728\u9996\u6b21 CAR T \u7ec6\u80de\u6cbb\u7597<\/li>\n
    2. \u5df2\u8bc1\u660e PI3K\u03b4 \u6291\u5236\u5242 parsaclisib \u53ef\u6709\u6548\u6cbb\u7597 R\/R \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/li>\n
    3. polatuzumab vedotin \u5728\u672a\u7ecf\u6cbb\u7597\u7684\u5f25\u6f2b\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u4e9a\u6d32\u60a3\u8005\u4e2d\u8bc1\u5b9e\u5177\u6709\u4e34\u5e8a\u83b7\u76ca<\/li>\n
    4. Rezivertinib \u5728\u7ecf\u6cbb\u7684 EGFR T790M \u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027 NSCLC \u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u9887\u5177\u524d\u666f\u7684\u4e34\u5e8a\u7ed3\u5c40<\/li>\n
    5. Taletrectinib \u5728 TKI \u521d\u6cbb\u6216\u8d5b\u53ef\u745e \u00ae \u7ecf\u6cbb\u7684 ROS1 \u9633\u6027 NSCLC \u4e2d\u56fd\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6709\u610f\u4e49\u7684\u4e34\u5e8a\u6709\u6548\u6027<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      \u4e3a\u4e86\u786e\u5b9a\u672c\u5e74\u5ea6\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b\u5185\u5bb9\uff0c\u79d1\u777f\u552f\u5b89\u80bf\u7624\u5b66\u4e13\u5bb6\u56e2\u961f\u4ed4\u7ec6\u7814\u7a76\u4e86\u4eca\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u53d1\u5e03\u7684\u6570\u5343\u7bc7\u6587\u732e\u6458\u8981\u3002\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u4e2a\u660e\u663e\u8d8b\u52bf\uff1a\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u548c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7b49\u521b\u65b0\u7597\u6cd5\u6210\u4e3a\u5173\u6ce8\u7126\u70b9\u3002 \u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u548c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5e76\u4e0d\u662f\u65b0\u578b\u836f\u7269\u3002\u5728\u8fc7\u53bb\u4e8c\u5341\u591a\u5e74\u91cc\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u5df2\u7ecf\u6279\u51c6\u4e86\u5341\u51e0\u79cd\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u4ee5\u53ca\u4e09\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7528\u4e8e\u80bf\u7624\u9002\u5e94\u75c7\u3002\u5728\u8fc7\u53bb\u4e09\u5e74\u91cc\uff0c\u6279\u51c6\u7684\u901f\u5ea6\u660e\u663e\u52a0\u5feb\u3002 \u73b0\u5728\uff0c\u5404\u5927\u836f\u4f01\u4e89\u76f8\u5f00\u53d1\u6b64\u7c7b\u5019\u9009\u836f\u54c1\uff0c\u5168\u529b\u63a8\u8fdb\u8fd9\u4e9b\u521b\u65b0\u7597\u6cd5\uff0c\u4ee5\u6539\u5584\u80bf\u7624\u60a3\u8005\u7ed3\u5c40\u3002\u4f8b\u5982\uff0c\u7b2c\u4e00\u4e09\u5171\u548c\u963f\u65af\u5229\u5eb7\u6b63\u5728\u4f7f\u7528\u8054\u5408\u5f00\u53d1\u7684 ADC \u836f\u7269 ENHERTU \u7684 3 \u671f\u8bd5\u9a8c\u7ed3\u679c\u7ee7\u7eed\u81f4\u529b\u4e8e\u6269\u5927 HER2 \u9776\u5411\u6cbb\u7597\u8303\u56f4\uff0c\u4ee5\u6cbb\u7597 HER2 \u4f4e\u8868\u8fbe\u60a3\u8005\u3002\u8be5 DESTINY BREAST03 \u8bd5\u9a8c\u53ef\u80fd\u4f1a\u91cd\u65b0\u754c\u5b9a\u4e73\u817a\u764c\u7684\u5206\u7c7b\u3002 \u5f53\u7136\uff0cADC \u548c\u53cc\u6297\u5e76\u4e0d\u662f\u4eca\u5e74\u4f1a\u8bae\u4e0a\u5d2d\u9732\u950b\u8292\u7684\u552f\u4e00\u6cbb\u7597\u65b9\u6cd5\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e00\u9879\u9488\u5bf9\u65e7\u5f0f\u6297 PD-1 \u5355\u514b\u9686\u6297\u4f53 dostarlimab\uff08Jemperli\uff09\u7684\u6781\u5c0f\u578b\u8bd5\u9a8c\u5360\u636e\u4e86\u7279\u522b\u62a5\u9053\u5916\u7684\u5927\u591a\u6570\u5934\u6761\u3002\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u6797\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u62a5\u544a\u79f0\uff0c\u5728\u4e00\u9879 2 \u671f\u7814\u7a76\u4e2d\uff0c14 \u540d\u76f4\u80a0\u764c\u60a3\u8005\u5747\u5b8c\u5168\u7f13\u89e3\u3002\u8fd9\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u5e0c\u671b\uff1a\u6216\u8bb8\u6709\u4e00\u5929\uff0c\u5728\u4e0d\u8fdb\u884c\u624b\u672f\u3001\u5316\u7597\u548c\u653e\u7597\u7684\u60c5\u51b5\u4e0b\u4ec5\u9760\u514d\u75ab\u7597\u6cd5\u5c31\u8db3\u4ee5\u6cbb\u7597\u67d0\u4e9b\u764c\u75c7\u3002 Jemperli \u7531\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u5f00\u53d1\uff0c\u81ea 2021 \u5e74 4 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