{"id":241689,"date":"2024-11-19T08:28:47","date_gmt":"2024-11-19T08:28:47","guid":{"rendered":"https:\/\/www.clarivate.com.cn\/?p=241689"},"modified":"2026-03-12T08:17:31","modified_gmt":"2026-03-12T08:17:31","slug":"drug-combinations-your-questions-answered","status":"publish","type":"post","link":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/blog\/drug-combinations-your-questions-answered\/","title":{"rendered":"\u836f\u7269\u7ec4\u5408\uff1a\u60a8\u7684\u95ee\u9898\u5df2\u5f97\u5230\u89e3\u7b54"},"content":{"rendered":"<p>\u5f00\u53d1\u836f\u7269\u7ec4\u5408\u662f\u4e00\u4e2a\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u65e2\u6709\u6311\u6218\u4e5f\u6709\u673a\u9047\uff0c\u53ef\u80fd\u4f1a\u5bf9\u60a3\u8005\u7684\u7ed3\u5c40\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002\u764c\u75c7\u7b49\u75be\u75c5\u901a\u5e38\u6d89\u53ca\u591a\u79cd\u5206\u5b50\u9014\u5f84\uff0c\u56e0\u6b64\u5355\u4e00\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u53ef\u80fd\u4e0d\u8db3\u3002\u56e0\u6b64\uff0c\u4eba\u4eec\u5bf9\u53ef\u540c\u65f6\u9488\u5bf9\u75be\u75c5\u4e0d\u540c\u65b9\u9762\u7684\u8054\u5408\u7597\u6cd5\u7684\u5174\u8da3\u65e5\u76ca\u6d53\u539a\u3002\u7136\u800c\uff0c\u7531\u4e8e\u79d1\u5b66\u3001\u7ecf\u6d4e\u3001\u76d1\u7ba1\u548c\u7269\u6d41\u7b49\u65b9\u9762\u5b58\u5728\u969c\u788d\uff0c\u56e0\u6b64\u5f00\u53d1\u8fd9\u4e9b\u8054\u5408\u7597\u6cd5\u4ea6\u975e\u5e38\u56f0\u96be\u3002<\/p>\n<p>\u6211\u4eec\u5728\u6700\u8fd1\u7684\u4e13\u9898\u8ba8\u8bba\u4f1a\u201c<a 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\u6846\u67b6\u6982\u8ff0\u4e86\u7531\u591a\u79cd\u6210\u5206\u7ec4\u6210\u7684\u4ea7\u54c1\u7684\u76d1\u7ba1\u9014\u5f84\u548c\u6ce8\u610f\u4e8b\u9879\u3002<\/p>\n<p>\u867d\u7136\u7ec4\u5408\u672a\u83b7\u6279\u4ea7\u54c1\u5e26\u6765\u4e86\u72ec\u7279\u7684\u6311\u6218\uff0c\u4f46 FDA \u7684\u6846\u67b6\u4e3a\u6b64\u63d0\u4f9b\u4e86\u8bc4\u4f30\u9014\u5f84\uff0c\u5f3a\u8c03\u9700\u8981\u63d0\u4f9b\u5168\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc1\u636e\u3002\u5efa\u8bae\u5728\u5f00\u53d1\u65e9\u671f\u4e0e FDA \u8fdb\u884c\u6c9f\u901a\uff0c\u4ee5\u4fbf\u6709\u6548\u5e94\u5bf9\u76d1\u7ba1\u73af\u5883\u3002<\/p>\n<h3>\u95ee\u9898\uff1a\u5728\u5171\u540c\u5f00\u53d1\u65b0\u578b\u4ea7\u54c1\u7684\u60c5\u51b5\u4e0b\uff0cFDA \u548c EMA \u662f\u5426\u671f\u671b\u5728\u9996\u4e2a\u5171\u540c\u5f00\u53d1\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\uff0c\u6216\u662f\u53ef\u4ee5\u5728\u5b8c\u6210\u9996\u4e2a\u5171\u540c\u5f00\u53d1\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u540e\u8bc1\u660e\u8fd9\u4e00\u70b9\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u5728\u5171\u540c\u5f00\u53d1\u65b0\u578b\u4ea7\u54c1\u7684\u80cc\u666f\u4e0b\uff0cFDA \u548c EMA \u5bf9\u8bc4\u4f30\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\u5747\u6709\u5177\u4f53\u7684\u671f\u671b\u3002<\/p>\n<ul>\n<li>FDA \u7684\u89c2\u70b9\uff1a<\/li>\n<\/ul>\n<p>\u521d\u59cb\u8bd5\u9a8c\uff1aFDA \u901a\u5e38\u671f\u671b\u9996\u4e2a\u5171\u540c\u5f00\u53d1\u8bd5\u9a8c\u5e94\u8bc4\u4f30 CP \u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4f46 FDA \u4e5f\u8ba4\u8bc6\u5230\uff0c\u5728\u65e9\u671f\u8bd5\u9a8c\u4e2d\u5206\u79bb\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\u53ef\u80fd\u5e76\u4e0d\u603b\u662f\u53ef\u884c\u7684\uff0c\u5c24\u5176\u5f53\u4e3b\u8981\u76ee\u7684\u4e3a\u786e\u5b9a\u9a8c\u8bc1\u6982\u5ff5\u65f6\u3002<\/p>\n<p>\u540e\u7eed\u7814\u7a76\uff1a\u53ef\u4ee5\u5728\u540e\u7eed\u7814\u7a76\u4e2d\u8bc1\u660e\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\u3002FDA \u9f13\u52b1\u91c7\u7528\u7075\u6d3b\u7684\u65b9\u6cd5\uff0c\u5728\u786e\u5b9a\u521d\u59cb\u6982\u5ff5\u9a8c\u8bc1\u540e\uff0c\u7533\u529e\u65b9\u53ef\u4ee5\u8ba1\u5212\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u4ee5\u533a\u5206\u5404\u4e2a\u6210\u5206\u7684\u4f5c\u7528\u3002<\/p>\n<ul>\n<li>EMA \u7684\u89c2\u70b9\uff1a<\/li>\n<\/ul>\n<p>\u9996\u6b21\u8bd5\u9a8c\u8003\u91cf\uff1aEMA \u671f\u671b\u9996\u6b21\u6982\u5ff5\u9a8c\u8bc1\u8bd5\u9a8c\u4e5f\u5e94\u8003\u8651\u5404\u4e2a\u6210\u5206\u7684\u5404\u79cd\u76f8\u4e92\u4f5c\u7528\u548c\u8d21\u732e\u3002\u7136\u800c\uff0c\u4e0e FDA \u7c7b\u4f3c\uff0cEMA \u627f\u8ba4\u5728\u65e9\u671f\u8bd5\u9a8c\u4e2d\u53ef\u80fd\u65e0\u6cd5\u8fdb\u884c\u5168\u9762\u8bc4\u4f30\u3002<\/p>\n<p>\u5355\u72ec\u8bc4\u4f30\uff1aEMA \u901a\u5e38\u503e\u5411\u4e8e\u5728\u5f00\u53d1\u8ba1\u5212\u4e2d\u660e\u786e\u5217\u51fa\u4efb\u4f55\u65e8\u5728\u8bc4\u4f30\u5404\u4e2a\u6210\u5206\u5355\u72ec\u8d21\u732e\u7684\u540e\u7eed\u7814\u7a76\u3002\u76d1\u7ba1\u673a\u6784\u671f\u671b\u603b\u4f53\u5f00\u53d1\u7b56\u7565\u6700\u7ec8\u4f1a\u6db5\u76d6\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\uff0c\u4ee5\u786e\u4fdd\u5168\u9762\u7406\u89e3\u4ea7\u54c1\u7279\u6027\u3002<\/p>\n<p>\u867d\u7136 FDA \u548c EMA \u5747\u5141\u8bb8\u91c7\u7528\u7075\u6d3b\u7684\u65b9\u5f0f\u8bc1\u660e\u5404\u4e2a\u6210\u5206\u7684\u8d21\u732e\uff0c\u4f46\u4ed6\u4eec\u66f4\u5e0c\u671b\u81f3\u5c11\u5728\u521d\u59cb\u8bd5\u9a8c\u4e2d\u5c31\u5df2\u5f00\u59cb\u8bc4\u4f30\u8fd9\u4e9b\u8d21\u732e\uff0c\u7279\u522b\u662f\u5728\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u65b9\u9762\u3002\u5236\u5b9a\u4e00\u4e2a\u53ef\u6e05\u6670\u6982\u8ff0\u5728\u6574\u4e2a\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u5982\u4f55\u8bc4\u4f30\u8fd9\u4e9b\u8d21\u732e\u7684\u5f00\u53d1\u8ba1\u5212\u5bf9\u8fd9\u4e24\u4e2a\u76d1\u7ba1\u673a\u6784\u90fd\u5f88\u91cd\u8981\u3002\u901a\u8fc7\u9012\u4ea4\u524d\u4f1a\u8bae\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u6c9f\u901a\u6709\u52a9\u4e8e\u660e\u786e\u5bf9\u7279\u5b9a\u5171\u540c\u5f00\u53d1\u60c5\u666f\u7684\u671f\u671b\u3002<\/p>\n<h3>\u95ee\u9898\uff1a\u5728\u6d89\u53ca\u4e24\u4e2a\u65b0\u578b\u751f\u7269\u5236\u54c1\u5171\u540c\u5f00\u53d1\u7684\u60c5\u51b5\u4e0b\uff0c\u76d1\u7ba1\u673a\u6784\u662f\u5426\u671f\u671b\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u5b8c\u6210\u9488\u5bf9\u5404\u4e2a\u836f\u7269\u7684\u5242\u91cf\u63a2\u7d22\u7814\u7a76\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u5728\u6d89\u53ca\u4e24\u4e2a\u65b0\u578b\u751f\u7269\u5236\u54c1\u5171\u540c\u5f00\u53d1\u7684\u60c5\u51b5\u4e0b\uff0cFDA \u548c EMA \u5173\u4e8e\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u7684\u76d1\u7ba1\u671f\u671b\u6709\u6240\u4e0d\u540c\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u5171\u6027\u3002<\/p>\n<ul>\n<li>FDA \u7684\u89c2\u70b9\uff1a<\/li>\n<\/ul>\n<p>\u5242\u91cf\u63a2\u7d22\u7814\u7a76\uff1aFDA \u901a\u5e38\u671f\u671b\u5728\u542f\u52a8\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u5bf9\u5404\u4e2a\u751f\u7269\u5236\u54c1\u8fdb\u884c\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u3002\u8fd9\u5bf9\u4e8e\u4e3a\u6bcf\u4e2a\u6210\u5206\u786e\u5b9a\u5b89\u5168\u6709\u6548\u7684\u5242\u91cf\u8303\u56f4\u5c24\u4e3a\u91cd\u8981\uff0c\u4ece\u800c\u53ef\u4e3a\u7ec4\u5408\u7814\u7a76\u7684\u8bbe\u8ba1\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n<p>\u63d0\u51fa\u5171\u540c\u5f00\u53d1\uff1a\u867d\u7136\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u62e5\u6709\u5242\u91cf\u63a2\u7d22\u6570\u636e\u662f\u6709\u5229\u7684\uff0c\u4f46 FDA \u53ef\u4ee5\u7075\u6d3b\u5904\u7406\u3002\u5982\u679c CP \u7684\u7406\u8bba\u4f9d\u636e\u652f\u6301\u540c\u65f6\u5bf9\u4e24\u79cd\u751f\u7269\u5236\u54c1\u8fdb\u884c\u8bc4\u4f30\uff0c\u5219\u7533\u529e\u65b9\u53ef\u4ee5\u63d0\u51fa\u4e00\u4e2a\u5171\u540c\u5f00\u53d1\u8ba1\u5212\uff0c\u5176\u4e2d\u5305\u62ec\u57fa\u4e8e\u521d\u6b65\u7ed9\u836f\u6570\u636e\u5bf9\u8be5 CP \u8fdb\u884c\u8bc4\u4f30\u7684\u521d\u59cb\u8bd5\u9a8c\u3002<br \/>\n\u5728\u5f00\u53d1\u65e9\u671f\u4e0e FDA \u8fdb\u884c\u6c9f\u901a\u6709\u52a9\u4e8e\u660e\u786e\u5728\u5f00\u59cb\u5171\u540c\u5f00\u53d1\u524d\u6240\u9700\u7684\u5242\u91cf\u63a2\u7d22\u6570\u636e\u3002<\/p>\n<ul>\n<li>EMA \u7684\u89c2\u70b9\uff1a<\/li>\n<\/ul>\n<p>\u5242\u91cf\u63a2\u7d22\u7814\u7a76\uff1aEMA \u4e5f\u901a\u5e38\u671f\u671b\u5728\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u5bf9\u5404\u4e2a\u751f\u7269\u5236\u54c1\u8fdb\u884c\u5242\u91cf\u63a2\u7d22\u7814\u7a76\uff0c\u7279\u522b\u662f\u4e3a\u4e86\u786e\u4fdd\u60a3\u8005\u7684\u5b89\u5168\u548c\u4f18\u5316\u7ed9\u836f\u7b56\u7565\u3002<\/p>\n<p>\u7ec4\u5408\u8bd5\u9a8c\uff1a\u5982\u679c\u5df2\u786e\u5b9a\u751f\u7269\u5236\u54c1\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u4e14\u8be5\u7ec4\u5408\u7684\u7406\u8bba\u4f9d\u636e\u5145\u5206\uff0cEMA \u53ef\u80fd\u5141\u8bb8\u540c\u65f6\u8fdb\u884c\u5171\u540c\u5f00\u53d1\uff0c\u4f46\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c\u5728\u6b64\u4e4b\u524d\u5e94\u63d0\u4f9b\u5404\u4e2a\u6210\u5206\u7684\u5145\u5206\u6570\u636e\u3002<\/p>\n<p>\u5f00\u53d1\u8ba1\u5212\uff1a\u5236\u5b9a\u4e00\u4e2a\u6982\u8ff0\u5982\u4f55\u5c06\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u6574\u5408\u5230\u5171\u540c\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4e14\u5b9a\u4e49\u660e\u786e\u7684\u5f00\u53d1\u8ba1\u5212\u662f\u6709\u76ca\u7684\u3002EMA \u9f13\u52b1\u5c31\u6240\u63d0\u51fa\u7684\u5f00\u53d1\u7b56\u7565\u7684\u7406\u8bba\u4f9d\u636e\u8fdb\u884c\u660e\u786e\u6c9f\u901a\u3002<\/p>\n<p>FDA \u548c EMA \u5747\u66f4\u503e\u5411\u4e8e\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u5b8c\u6210\u5bf9\u5404\u4e2a\u751f\u7269\u5236\u54c1\u7684\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u3002\u7136\u800c\uff0c\u6839\u636e\u5177\u4f53\u60c5\u51b5\u3001\u5b89\u5168\u6027\u8003\u91cf\u4ee5\u53ca\u8054\u5408\u7597\u6cd5\u7406\u8bba\u4f9d\u636e\u7684\u5f3a\u5ea6\uff0c\u53ef\u80fd\u4f1a\u5b58\u5728\u4e00\u5b9a\u7684\u7075\u6d3b\u6027\u3002\u5efa\u8bae\u5728\u5f00\u53d1\u65e9\u671f\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u6c9f\u901a\uff0c\u4ee5\u786e\u4fdd\u5bf9\u671f\u671b\u548c\u7814\u7a76\u8bbe\u8ba1\u8fbe\u6210\u5171\u8bc6\u3002<\/p>\n<h3>\u95ee\uff1a\u5728\u6d89\u53ca\u4e24\u4e2a\u65b0\u578b\u751f\u7269\u5236\u54c1\u5171\u540c\u5f00\u53d1\u7684\u60c5\u51b5\u4e0b\uff0c\u76d1\u7ba1\u673a\u6784\u662f\u5426\u671f\u671b\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u8bc1\u660e\u5404\u4e2a\u836f\u7269\u7684\u6709\u6548\u6027\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u5728\u6d89\u53ca\u4e24\u4e2a\u65b0\u578b\u751f\u7269\u5236\u54c1\u5171\u540c\u5f00\u53d1\u7684\u60c5\u51b5\u4e0b\uff0cFDA \u548c EMA \u5bf9\u4e8e\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u8bc1\u660e\u5404\u4e2a\u836f\u7269\u6709\u6548\u6027\u7684\u76d1\u7ba1\u671f\u671b\u6709\u6240\u4e0d\u540c\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u5171\u6027\u3002<\/p>\n<p>FDA \u7684\u89c2\u70b9\uff1a<\/p>\n<ul>\n<li>\u6709\u6548\u6027\u8bc1\u636e\uff1aFDA \u901a\u5e38\u671f\u671b\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\uff0c\u5404\u4e2a\u751f\u7269\u5236\u54c1\u90fd\u5e94\u8be5\u6709\u4e00\u4e9b\u6709\u6548\u6027\u8bc1\u636e\u3002\u8fd9\u5bf9\u4e8e\u786e\u4fdd\u6bcf\u79cd\u6210\u5206\u5747\u5177\u6709\u7ecf\u8bc1\u5b9e\u7684\u6cbb\u7597\u83b7\u76ca\u5c24\u4e3a\u91cd\u8981\uff0c\u4ece\u800c\u53ef\u652f\u6301\u5176\u7ec4\u5408\u7684\u7406\u8bba\u4f9d\u636e\u3002<\/li>\n<li>\u63d0\u51fa\u5171\u540c\u5f00\u53d1\uff1a\u867d\u7136\u7406\u60f3\u60c5\u51b5\u662f\u786e\u5b9a\u4e24\u79cd\u6210\u5206\u7684\u6709\u6548\u6027\uff0c\u4f46\u5982\u679c\u6709\u5f3a\u6709\u529b\u7684\u79d1\u5b66\u4f9d\u636e\uff0c\u6216\u8005\u5355\u4e2a\u751f\u7269\u5236\u54c1\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u6570\u636e\u548c\u660e\u786e\u7684\u4f5c\u7528\u673a\u5236\uff0c\u8868\u660e\u7ec4\u5408\u65f6\u53ef\u80fd\u5b58\u5728\u6f5c\u5728\u7684\u53e0\u52a0\u6216\u534f\u540c\u4f5c\u7528\uff0cFDA \u53ef\u80fd\u4f1a\u5141\u8bb8\u8fdb\u884c\u5171\u540c\u5f00\u53d1\u3002<\/li>\n<li>\u4e0e FDA \u7684\u6c9f\u901a\uff1a\u9f13\u52b1\u7533\u529e\u8005\u5728 pre-IND \u4f1a\u8bae\u671f\u95f4\u4e0e FDA \u8fdb\u884c\u8ba8\u8bba\uff0c\u4ee5\u9610\u660e\u5bf9\u6709\u6548\u6027\u6570\u636e\u7684\u671f\u671b\u4ee5\u53ca\u5176\u4e0e\u5171\u540c\u5f00\u53d1\u8ba1\u5212\u7684\u5173\u7cfb\u3002<\/li>\n<\/ul>\n<p>EMA \u7684\u89c2\u70b9\uff1a<\/p>\n<ul>\n<li>\u6709\u6548\u6027\u7684\u8bc1\u660e\uff1aEMA \u4e5f\u901a\u5e38\u671f\u671b\u5728\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u786e\u5b9a\u5404\u4e2a\u751f\u7269\u5236\u54c1\u7684\u6709\u6548\u6027\u3002\u8fd9\u6709\u52a9\u4e8e\u786e\u4fdd\u4e24\u79cd\u6210\u5206\u5747\u5177\u6709\u7ecf\u9a8c\u8bc1\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5bf9\u4e8e\u8bc1\u660e\u5176\u7ec4\u5408\u7684\u5408\u7406\u6027\u81f3\u5173\u91cd\u8981\u3002<\/li>\n<li>\u7ec4\u5408\u7814\u7a76\uff1a\u5982\u679c\u5355\u4e2a\u751f\u7269\u5236\u54c1\u5728\u5b89\u5168\u6027\u548c\u521d\u6b65\u6709\u6548\u6027\u65b9\u9762\u663e\u793a\u51fa\u826f\u597d\u7684\u524d\u666f\uff0c\u5e76\u4e14\u8be5\u7ec4\u5408\u5177\u6709\u4ee4\u4eba\u4fe1\u670d\u7684\u79d1\u5b66\u4f9d\u636e\uff0c\u5219\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u53ef\u80fd\u662f\u53ef\u884c\u7684\u3002<\/li>\n<li>\u4e0e\u76d1\u7ba1\u673a\u6784\u7684\u6c9f\u901a\uff1a\u4e0e FDA \u7c7b\u4f3c\uff0c\u5efa\u8bae\u5728\u5f00\u53d1\u65e9\u671f\u4e0e EMA \u8fdb\u884c\u6c9f\u901a\uff0c\u4ee5\u4e86\u89e3\u5177\u4f53\u7684\u6570\u636e\u8981\u6c42\u5e76\u5c31\u63d0\u51fa\u7684\u5f00\u53d1\u7b56\u7565\u8fbe\u6210\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p>FDA \u548c EMA \u901a\u5e38\u5747\u671f\u671b\u5728\u63d0\u51fa\u5171\u540c\u5f00\u53d1\u4e4b\u524d\u8bc1\u660e\u5355\u4e2a\u751f\u7269\u5236\u54c1\u7684\u6709\u6548\u6027\u3002\u7136\u800c\uff0c\u6839\u636e\u5177\u4f53\u60c5\u51b5\u53ef\u80fd\u5b58\u5728\u4e00\u4e9b\u7075\u6d3b\u6027\uff0c\u7279\u522b\u662f\u5982\u679c\u8be5\u7ec4\u5408\u5177\u6709\u5f3a\u6709\u529b\u7684\u79d1\u5b66\u4f9d\u636e\u3002\u5efa\u8bae\u5728\u6d41\u7a0b\u7684\u65e9\u671f\u4e0e\u76d1\u7ba1\u673a\u6784\u63a5\u89e6\uff0c\u4ee5\u786e\u4fdd\u671f\u671b\u548c\u7814\u7a76\u8bbe\u8ba1\u7684\u4e00\u81f4\u6027\u3002<\/p>\n<h3>\u95ee\u9898\uff1a\u5173\u4e8e FDA\uff0c\u6211\u4eec\u662f\u5426\u53ef\u4ee5\u7406\u89e3\u4e3a\u5728 CP \u83b7\u6279\u524d\uff0c\u6bcf\u79cd\u6210\u5206\u90fd\u9700\u8981\u83b7\u5f97\u6279\u51c6\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u901a\u5e38\u60c5\u51b5\u4e0b\uff0cFDA \u5e76\u4e0d\u8981\u6c42 CP \u7684\u6bcf\u79cd\u6210\u5206\u5728\u7ec4\u5408\u672c\u8eab\u83b7\u6279\u524d\u5747\u5355\u72ec\u83b7\u5f97\u6279\u51c6\u3002\u7136\u800c\uff0c\u6709\u4e00\u4e9b\u91cd\u8981\u7684\u7ec6\u5fae\u5dee\u522b\u9700\u8981\u8003\u8651\uff1a<\/p>\n<ul>\n<li>\u65e0\u9700\u83b7\u5f97\u5355\u72ec\u6279\u51c6\uff1a\u5373\u4f7f\u5404\u4e2a\u6210\u5206\u5c1a\u672a\u83b7\u5f97\u6279\u51c6\uff0cFDA \u4e5f\u53ef\u80fd\u6279\u51c6 CP\u3002CP \u7684\u6279\u51c6\u8fc7\u7a0b\u5c06\u5bf9\u6574\u4e2a\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4f30\u3002<\/li>\n<li>\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc1\u636e\uff1a\u867d\u7136\u4e0d\u9700\u8981\u4e8b\u5148\u6279\u51c6\u5404\u4e2a\u6210\u5206\uff0c\u4f46 FDA \u671f\u671b\u63d0\u4f9b\u6709\u5173 CP \u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u5145\u5206\u8bc1\u636e\u3002\u8fd9\u53ef\u80fd\u5305\u62ec\u4e13\u95e8\u4e3a\u8be5 CP \u8bbe\u8ba1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002<\/li>\n<li>\u76d1\u7ba1\u9014\u5f84\uff1aCP \u7684\u76d1\u7ba1\u9014\u5f84\u53d6\u51b3\u4e8e\u5176\u4e3b\u8981\u4f5c\u7528\u673a\u5236\u3002\u5982\u679c CP \u65e8\u5728\u5171\u540c\u4f7f\u7528\uff0cFDA \u5219\u5c06\u5176\u89c6\u4e3a\u4e00\u4e2a\u72ec\u7279\u7684\u5b9e\u4f53\u8fdb\u884c\u8bc4\u4f30\uff0c\u5e76\u8003\u8651\u6240\u6709\u6709\u5173\u6210\u5206\u53ca\u5176\u5404\u79cd\u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6570\u636e\u3002<\/li>\n<li>\u9012\u4ea4\u524d\u6c9f\u901a\uff1a\u901a\u8fc7\u9012\u4ea4\u524d\u4f1a\u8bae\u4e0e FDA \u8fdb\u884c\u6c9f\u901a\u6709\u52a9\u4e8e\u660e\u786e\u5bf9\u7279\u5b9a CP \u7684\u671f\u671b\u548c\u8981\u6c42\uff08\u7279\u522b\u662f\u6279\u51c6\u6240\u9700\u7684\u8bc1\u636e\uff09\u3002<\/li>\n<\/ul>\n<p>\u603b\u800c\u8a00\u4e4b\uff0c\u867d\u7136 FDA 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IIb \u671f\u7814\u7a76\u4e2d\uff0c\u60a8\u662f\u5426\u4e0e\u5355\u81c2\u8fdb\u884c\u4e86\u6bd4\u8f83?<\/h3>\n<p>\u56de\u7b54\uff1a\u5728 IIb \u671f\u7814\u7a76\u4e2d\uff0c\u901a\u5e38\u4f1a\u7eb3\u5165\u5bf9\u7167\u7ec4\uff08\u5982\u5355\u836f\u6cbb\u7597\u7ec4\uff09\u4ee5\u8bc4\u4f30\u7814\u7a76\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7eb3\u5165\u5355\u836f\u6cbb\u7597\u7ec4\u4f7f\u7814\u7a76\u8005\u80fd\u591f\u5c06\u8054\u5408\u7597\u6cd5\u7684\u6548\u679c\u4e0e\u6bcf\u79cd\u6210\u5206\u5355\u72ec\u7ed9\u836f\u65f6\u7684\u6548\u679c\u8fdb\u884c\u6bd4\u8f83\u3002<\/p>\n<p>\u8fd9\u79cd\u8bbe\u8ba1\u6709\u52a9\u4e8e\u786e\u5b9a\u8054\u5408\u7597\u6cd5\u662f\u5426\u5177\u6709\u53e0\u52a0\u6216\u534f\u540c\u4f5c\u7528\uff0c\u5e76\u53ef\u63d0\u4f9b\u5bf9\u6cbb\u7597\u603b\u4f53\u83b7\u76ca-\u98ce\u9669\u7279\u5f81\u7684\u89c1\u89e3\u3002\u7136\u800c\uff0c\u7814\u7a76\u7684\u5177\u4f53\u8bbe\u8ba1\uff08\u5305\u62ec\u662f\u5426\u8bbe\u6709\u5355\u836f\u6cbb\u7597\u7ec4\uff09\u5c06\u53d6\u51b3\u4e8e\u8bd5\u9a8c\u76ee\u7684\u548c\u6240\u8bc4\u4f30\u7597\u6cd5\u7684\u6027\u8d28\u3002<\/p>\n<p>\u5982\u679c\u60a8\u8003\u8651\u8fdb\u884c\u4e00\u9879\u7279\u5b9a\u7814\u7a76\uff0c\u7814\u7a76\u65b9\u6848\u6216\u5df2\u53d1\u8868\u7684\u7ed3\u679c\u5c06\u63d0\u4f9b\u5173\u4e8e\u5355\u836f\u6cbb\u7597\u7ec4\u7684\u7eb3\u5165\u548c\u6240\u4f7f\u7528\u7684\u6bd4\u8f83\u65b9\u6cd5\u7684\u6700\u51c6\u786e\u7ec6\u8282\u3002<\/p>\n<h3>\u95ee\u9898\uff1a\u673a\u6784\u5982\u4f55\u8bc6\u522b\u5206\u5b50\u5e76\u5bfb\u627e\u8fd9\u79cd\u7ec4\u5408\u7684\u5e02\u573a\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u8ba1\u7b97\u65b9\u6cd5\u5bf9\u4e8e\u9884\u6d4b\u6709\u6548\u7684\u836f\u7269\u7ec4\u5408\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u6574\u5408\u548c\u5206\u6790\u5927\u91cf\u7684\u751f\u7269\u6570\u636e\u3002\u76ee\u524d\u6700\u6d41\u884c\u7684\u65b9\u6cd5\u57fa\u4e8e\u7cfb\u7edf\u751f\u7269\u5b66\u3001\u673a\u5668\u5b66\u4e60\uff08Machine Learning\uff0cML\uff09\u6216\u4e8c\u8005\u7684\u7ed3\u5408\u3002\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u57fa\u4e8e\u5bf9\u751f\u7269\u7f51\u7edc\u7684\u5206\u6790\uff0c\u9700\u8981\u5e7f\u6cdb\u7684\u751f\u7269\u5b66\u77e5\u8bc6\u3002ML \u6a21\u578b\u5c1d\u8bd5\u4ece\u6570\u636e\u4e2d\u5b66\u4e60\u590d\u6742\u7684\u6a21\u5f0f\uff0c\u4f46\u53d7\u9650\u4e8e\u8bad\u7ec3\u6570\u636e\u7684\u6570\u91cf\u3002\u65b9\u6cd5\u7684\u9009\u62e9\u53d6\u51b3\u4e8e\u6240\u5173\u6ce8\u6cbb\u7597\u9886\u57df\u53ef\u7528\u6570\u636e\u7684\u6570\u91cf\u3002<\/p>\n<p>\u79d1\u777f\u552f\u5b89\u7684\u53d1\u73b0\u548c\u8f6c\u5316\u79d1\u5b66\u54a8\u8be2\u56e2\u961f\u5728\u5b9e\u65bd\u6b64\u7c7b\u65b9\u6cd5\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7ecf\u9a8c\u3002\u5bf9\u4e8e\u4e00\u4e9b\u5e26\u7740\u7279\u5b9a\u9002\u5e94\u75c7\u524d\u6765\u7684\u5ba2\u6237\uff0c\u6211\u4eec\u53ef\u4ee5\u5206\u4e24\u6b65\u8fdb\u884c\uff1a<\/p>\n<ol>\n<li>\u9996\u5148\uff0c\u4f7f\u7528 ML \u7ba1\u9053\uff0c\u5229\u7528\u7ecf\u8fc7\u6574\u7406\u7684\u5206\u5b50\u5404\u79cd\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u5e93\uff08Database\uff0cDB\uff09\uff08Metabase\uff09\u548c Cortellis \u836f\u7269\u65e9\u671f\u7814\u53d1\u60c5\u62a5\u4e2d\u7684\u4fe1\u606f\u4e3a\u8fd9\u4e9b\u9002\u5e94\u75c7\u7684\u9776\u70b9\u8fdb\u884c\u4f18\u5148\u6392\u5e8f\uff1b<\/li>\n<li>\u7136\u540e\uff0c\u786e\u5b9a\u9488\u5bf9\u8fd9\u4e9b\u9776\u70b9\u4f7f\u7528\u7684\u836f\u7269\uff0c\u5e76\u4f7f\u7528\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u9884\u6d4b\u8fd9\u4e9b\u7ec4\u5408\u7684\u6548\u679c\u3002<\/li>\n<\/ol>\n<p>\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\uff0c\u9488\u5bf9\u5ba2\u6237\u611f\u5174\u8da3\u7684\u67d0\u79cd\u836f\u7269\uff0c\u6211\u4eec\u4f1a\u4f7f\u7528\u8ba1\u7b97\u65b9\u6cd5\uff08\u65e0\u8bba\u662f ML \u8fd8\u662f\u7cfb\u7edf\u751f\u7269\u5b66\uff09\u4e3a\u5176\u5bfb\u627e\u8be5\u836f\u7269\u7684\u6700\u4f73\u642d\u914d\u4f19\u4f34\u3002<\/p>\n<p>\u6700\u540e\uff0c\u4e3a\u4e86\u786e\u5b9a\u8fd9\u79cd\u7ec4\u5408\u7684\u5e02\u573a\uff0c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u53ef\u4ee5\u53d1\u6325\u5de8\u5927\u7684\u4f5c\u7528\u3002\u6d41\u884c\u75c5\u5b66\u6570\u636e\u53ef\u7528\u4e8e\u8bc4\u4f30\u5e02\u573a\u89c4\u6a21\u3002\u6b64\u5916\uff0c\u53ef\u4ee5\u501f\u52a9\u79d1\u777f\u552f\u5b89\u7684\u5e02\u573a\u8bc4\u4f30\u5de5\u5177\uff08\u5982 Cortellis \u7ade\u4e89\u60c5\u62a5\u6216\u75be\u75c5\u6982\u51b5\u4e0e\u9884\u6d4b\uff09\u83b7\u53d6\u5173\u4e8e\u4e13\u5229\u836f\u7269\u3001\u5e02\u573a\u8d8b\u52bf\u3001\u836f\u7269\u5f00\u53d1\u9636\u6bb5\u3001\u56e0\u6bd2\u6027\u800c\u7ec8\u6b62\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7b49\u4fe1\u606f\u3002\u79d1\u777f\u552f\u5b89\u5546\u4e1a\u6218\u7565\u54a8\u8be2\u670d\u52a1\u7684\u4e13\u5bb6\u53ef\u4ee5\u534f\u52a9\u60a8\u5b8c\u6210\u6b64\u4efb\u52a1\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-241690 size-full\" src=\"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2025\/01\/drug_combinations_picture1.png\" alt=\"\u533b\u836f\u7814\u53d1\u6570\u636e_\u836f\u7269\u65e9\u671f\u7814\u53d1\u60c5\u62a5\u6570\u636e\u5e93_\u4e34\u5e8a\u524d\u7814\u7a76\u60c5\u62a5_\u751f\u7269\u836f\u5f00\u53d1\" width=\"627\" height=\"531\" srcset=\"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2025\/01\/drug_combinations_picture1.png 627w, https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2025\/01\/drug_combinations_picture1-300x254.png 300w, https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/wp-content\/uploads\/sites\/4\/2025\/01\/drug_combinations_picture1-47x40.png 47w\" sizes=\"auto, (max-width: 627px) 100vw, 627px\" \/><\/p>\n<h3>\u95ee\u9898\uff1a\u60a8\u63d0\u5230\u53ef\u4ee5\u57fa\u4e8e\u4e34\u5e8a\u524d\u6a21\u578b\u9884\u6d4b CP \u7684\u5b89\u5168\u6027\u3002\u7531\u4e8e\u7ec4\u5408\u7684\u60c5\u51b5\u975e\u5e38\u590d\u6742\uff0c\u56e0\u6b64\u5bf9\u4eba\u7c7b\u5b89\u5168\u6027\u7684\u9884\u6d4b\u80fd\u529b\u5982\u4f55\uff1f<\/h3>\n<p>\u56de\u7b54\uff1a\u7684\u786e\uff0c\u5355\u51ed\u4e34\u5e8a\u524d\u6a21\u578b\u9884\u6d4b\u836f\u7269\u7ec4\u5408\u5728\u4eba\u7c7b\u4e2d\u7684\u5b89\u5168\u6027\u662f\u5177\u6709\u6311\u6218\u6027\u7684\u3002\u5c24\u5176\u5f53\u4e34\u5e8a\u524d\u6a21\u578b\u4e0d\u80fd\u51c6\u786e\u4ee3\u8868\u4eba\u7c7b\u75be\u75c5\u65f6\uff08\u4f8b\u5982\uff0c\u4f7f\u7528\u7ec6\u80de\u7cfb\u800c\u975e\u4e09\u7ef4\u7c7b\u5668\u5b98\uff09\u3002<\/p>\n<p>\u5728\u8fd9\u79cd\u7f3a\u4e4f\u76f8\u5173\u5b9e\u9a8c\u6570\u636e\u7684\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u503e\u5411\u4e8e\u4f7f\u7528\u4e0d\u4f9d\u8d56\u5b9e\u9a8c\u6570\u636e\u7684\u9884\u6d4b\u65b9\u6cd5\uff0c\u5229\u7528\u73b0\u6709\u7684\u836f\u7269\u548c\u75be\u75c5\u77e5\u8bc6\u3002\u5728\u6211\u4eec\u7684\u53d1\u73b0\u4e0e\u8f6c\u5316\u79d1\u5b66\u54a8\u8be2\u56e2\u961f\u4e2d\uff0c\u6211\u4eec\u901a\u5e38\u91c7\u7528\u4e24\u79cd\u4e3b\u8981\u65b9\u6cd5\uff1a\u76d1\u7763\u5f0f ML \u65b9\u6cd5\u548c\u57fa\u4e8e\u56fe\u7684\u65b9\u6cd5\uff1a<\/p>\n<p>\u57fa\u4e8e ML \u7684\u65b9\u6cd5\uff1a<\/p>\n<p>\u8be5\u65b9\u6cd5\u65e8\u5728\u9884\u6d4b\u6bd2\u6027\uff0c\u5177\u6709\u7075\u6d3b\u6027\uff0c\u56e0\u6b64\u53ef\u5728\u4f7f\u7528\u6216\u4e0d\u4f7f\u7528\u4efb\u4f55\u5b9e\u9a8c\u6027\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u4fe1\u606f\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u8bbe\u7f6e\u3002\u53ef\u5e94\u7528\u4e8e\u4e24\u79cd\u60c5\u5f62\uff1a<\/p>\n<ul>\n<li>\u5f53\u6211\u4eec\u62e5\u6709\u4ee3\u8868\u8be5\u75be\u75c5\u7684\u836f\u7269\u6216\u836f\u7269\u7ec4\u5408\u7684\u5b9e\u9a8c\u6570\u636e\uff08\u5982\u826f\u597d\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u3001\u4e34\u5e8a\u6570\u636e\u7b49\uff09\u65f6<\/li>\n<li>\u5f53\u6211\u4eec\u4f7f\u7528\u6709\u5173\u75be\u75c5\u751f\u7269\u6807\u5fd7\u7269\u3001\u901a\u8def\u3001\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08Protein-protein Interaction\uff0cPPI\uff09\u7b49\u751f\u7269\u4fe1\u606f\uff08\u4f8b\u5982\u6765\u81ea <a href=\"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/research-development\/discovery-development\/cortellis-pre-clinical-intelligence\/\">CDDI<\/a>\u3001<a href=\"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/research-development\/discovery-development\/early-research-intelligence-solutions\/\">Metabase<\/a>\uff09\u4ee5\u53ca\u836f\u7269\u7684\u5316\u5b66\u6027\u8d28\u4f5c\u4e3a\u8f93\u5165\u6570\u636e\u65f6\u3002<\/li>\n<\/ul>\n<p>\u57fa\u4e8e\u56fe\u7684\u65b9\u6cd5\uff1a<\/p>\n<ul>\n<li>\u8be5\u65b9\u6cd5\u76f4\u63a5\u5229\u7528\u5e76\u9884\u6d4b\u6765\u81ea OFF-X DB\uff08\u79d1\u777f\u552f\u5b89\u7684\u5b89\u5168\u6027\u6570\u636e\u5e93\uff09\u7684\u836f\u7269\u7ec4\u5408\u7684\u65b0\u6bd2\u6027\u6ce8\u91ca\uff0c\u4e14\u4e0d\u9700\u8981\u4efb\u4f55\u5b9e\u9a8c\u8f93\u5165\u6570\u636e\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5177\u6709\u826f\u597d\u7684\u9884\u6d4b\u80fd\u529b\uff08AUC&gt;0.8\uff09\u3002\u7136\u800c\uff0c\u5b83\u8981\u6c42\u7ec4\u5408\u4e2d\u7684\u836f\u7269\u81f3\u5c11\u6709\u4e00\u4e9b\u73b0\u6709\u7684\u6ce8\u91ca\uff0c\u56e0\u6b64\u53ef\u80fd\u4e0d\u9002\u7528\u4e8e\u5168\u65b0\u7684\u836f\u7269\uff08\u4f46\u8fd9\u5bf9\u836f\u7269\u7ec4\u5408\u6765\u8bf4\u901a\u5e38\u4e0d\u662f\u95ee\u9898\uff09\u3002<\/li>\n<\/ul>\n<p><em>\u70b9\u51fb<a href=\"https:\/\/clarivate.com\/life-sciences-healthcare\/webinars\/innovative-therapeutics-challenges-and-opportunities-in-developing-drug-combinations\/\" target=\"_blank\" rel=\"noopener\">\u6b64\u5904<\/a>\u67e5\u770b\u5b8c\u6574\u7684\u7f51\u7edc\u7814\u8ba8\u4f1a\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u79d1\u777f\u552f\u5b89\u7684\u53d1\u73b0\u548c\u4e34\u5e8a\u524d\u89e3\u51b3\u65b9\u6848\u5982\u4f55\u5e2e\u52a9\u521b\u65b0\u8005\u514b\u670d\u590d\u6742\u7684\u79d1\u5b66\u6311\u6218\uff0c\u8bf7\u70b9\u51fb<a href=\"https:\/\/clarivate.com\/life-sciences-healthcare\/lp\/case-study-unlocking-the-potential-of-advanced-computational-methods-in-drug-discovery\/\" target=\"_blank\" 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