{"id":434920,"date":"2025-05-28T07:21:27","date_gmt":"2025-05-28T07:21:27","guid":{"rendered":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/?p=434920"},"modified":"2026-03-12T08:09:27","modified_gmt":"2026-03-12T08:09:27","slug":"pharma-is-placing-bigger-bets-on-fewer-more-strategic-assets-platforms","status":"publish","type":"post","link":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/blog\/pharma-is-placing-bigger-bets-on-fewer-more-strategic-assets-platforms\/","title":{"rendered":"\u5236\u836f\u516c\u53f8\u6b63\u5728\u96c6\u4e2d\u8d44\u6e90\u62bc\u6ce8\u5c11\u6570\u66f4\u5177\u6218\u7565\u610f\u4e49\u7684\u8d44\u4ea7\/\u5e73\u53f0"},"content":{"rendered":"

\u5236\u836f\u516c\u53f8\u5728\u4ea4\u6613\u6d3b\u52a8\u4e2d\u6301\u7eed\u5173\u6ce8\u5982\u4f55\u6700\u5927\u5316\u4ef7\u503c\u5e76\u63a7\u5236\u98ce\u9669\u3002\u5c3d\u7ba1\u4ea4\u6613\u603b\u91cf\u6709\u6240\u4e0b\u964d\uff0c\u4f46 2024 \u5e74\u7684\u4ea4\u6613\u989d\u8fde\u7eed\u7b2c\u4e8c\u5e74\u521b\u4e0b\u5386\u53f2\u65b0\u9ad8\uff0c\u8fd9\u8868\u660e\u6218\u7565\u91cd\u5fc3\u8f6c\u5411\u4e86\u6570\u91cf\u66f4\u5c11\u4f46\u4ef7\u503c\u66f4\u9ad8\u7684\u4ea4\u6613\u3002\u8fd9\u4e00\u73af\u5883\u7684\u5f62\u6210\uff0c\u53d7\u5230\u4ee5\u4e0b\u56e0\u7d20\u7684\u5f71\u54cd\uff1a\u8feb\u5728\u7709\u776b\u7684\u4e13\u5229\u5230\u671f\u5a01\u80c1\u5230\u5de8\u989d\u6536\u5165\uff0c\u6301\u7eed\u9700\u8981\u901a\u8fc7\u521b\u65b0\u8d44\u4ea7\u8865\u5145\u7814\u53d1\u7ba1\u7ebf\uff0c\u4ee5\u53ca\u4e0d\u65ad\u53d8\u5316\u7684\u76d1\u7ba1\u73af\u5883\uff08\u65e2\u4fc3\u8fdb\u4e5f\u9650\u5236\u4e86\u4ea4\u6613\u6d3b\u52a8\uff09\u3002\u63a8\u52a8\u9009\u62e9\u6027\u6218\u7565\u4ea4\u6613\u5ba1\u614e\u590d\u82cf\u7684\u5173\u952e\u56e0\u7d20\u5305\u62ec\uff1a\u5bf9\u5546\u4e1a\u5316\u524d\u8d44\u4ea7\u3001\u5e73\u53f0\u6280\u672f\u548c\u9ad8\u5f71\u54cd\u529b\u6cbb\u7597\u9886\u57df\u7684\u5173\u6ce8\u3002<\/p>\n

\u6295\u8d44\u65e9\u671f\u9879\u76ee\u548c\u57fa\u4e8e\u5e73\u53f0\u7684\u836f\u7269\u53d1\u73b0<\/strong><\/h3>\n

2024 \u5e74\u7684\u4ea4\u6613\u91cd\u70b9\u4ecd\u7136\u662f\u901a\u8fc7\u5408\u4f5c\u5173\u7cfb\u6765\u586b\u8865\u7814\u53d1\u7ba1\u7ebf\u7684\u7a7a\u7f3a\uff0c\u8865\u5145\u73b0\u6709\u7684\u8d44\u4ea7\u7ec4\u5408\uff0c\u5e76\u5b9e\u73b0\u4e0e\u7ade\u4e89\u5bf9\u624b\u7684\u5dee\u5f02\u5316\u3002\u5236\u836f\u516c\u53f8\u5927\u80c6\u6295\u8d44\u5408\u9002\u7684\u76ee\u6807\uff1a\u6709 79 \u7b14\u4ea4\u6613\u989d\u8d85\u8fc7 10 \u4ebf\u7f8e\u5143\uff0c\u5408\u8ba1\u8d21\u732e\u4e86 1,501 \u4ebf\u7f8e\u5143\uff0c\u5360\u5168\u5e74\u603b\u4ea4\u6613\u989d\u7684 65%\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u4ea4\u6613\u5305\u62ec Sarepta Therapeutics \u516c\u53f8\u4e0e Arrowhead Pharmaceuticals \u516c\u53f8\u8fbe\u6210\u7684\u4ef7\u503c 128.2 \u4ebf\u7f8e\u5143\u7684\u8bb8\u53ef\u534f\u8bae\uff0c\u6d89\u53ca\u9488\u5bf9\u7f55\u89c1\u7684\u9057\u4f20\u6027\u808c\u8089\u9aa8\u9abc\u75be\u75c5\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u75be\u75c5\u548c\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u524d\u548c\u53d1\u73b0\u9636\u6bb5\u9879\u76ee\u3002\u8fd9\u4e9b\u9879\u76ee\u57fa\u4e8e Arrowhead Pharmaceuticals Inc. \u4e13\u6709\u7684\u9776\u5411\u6838\u7cd6\u6838\u9178\u5e72\u6270\uff08RNAi\uff09\u5206\u5b50\uff08TRiM\u2122\uff09\u5e73\u53f0\uff0c\u7528\u4e8e\u76ae\u4e0b\u9012\u9001\u5c0f\u5e72\u6270 RNA\uff08siRNA\uff09\u7597\u6cd5\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u5c06\u5408\u4f5c\u53d1\u73b0\u591a\u8fbe\u516d\u4e2a\u989d\u5916\u7684\u808c\u8089\u3001\u5fc3\u810f\u6216 CNS \u9776\u70b9\u3002<\/p>\n

\u8bfa\u534e\u5728 2024 \u5e74\u6392\u540d\u524d\u5341\u7684\u4ea4\u6613\u989d\u4e2d\u5360\u636e\u56db\u5e2d\uff0c\u5176 30 \u7b14\u4ea4\u6613\u4e2d\u6709 14 \u7b14\u62ab\u9732\u91d1\u989d\uff0c\u603b\u8ba1\u8fbe 213.1 \u4ebf\u7f8e\u5143\u3002\u8fd9\u4e9b\u4ea4\u6613\u5305\u62ec\uff1a\u5229\u7528\u4e0a\u6d77\u8236\u671b\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u7684 RNAi \u6280\u672f\u8fdb\u884c\u7684 1 \u671f\u5fc3\u8840\u7ba1\u9776\u70b9\u53d1\u73b0\u9879\u76ee\uff1b\u5229\u7528 Dren Bio Inc. \u4e13\u6709\u7684\u9776\u5411\u9ad3\u7cfb\u7ec6\u80de\u8854\u63a5\u4e0e\u541e\u566c\u5e73\u53f0\u8fdb\u884c\u7684\u6297\u764c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53d1\u73b0\u548c\u5f00\u53d1\u9879\u76ee\uff1b\u6765\u81ea PTC Therapeutics Inc. \u7684\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u9879\u76ee\u7b49\u3002\u6b64\u5916\uff0c\u8bfa\u534e\u65a5\u8d44\u9ad8\u8fbe 61.8 \u4ebf\u7f8e\u5143\u8fdb\u884c\u4e86\u516d\u9879\u6536\u8d2d\uff0c\u5176\u4e2d\u4e24\u9879\u672a\u62ab\u9732\u91d1\u989d\u3002\u5176\u4e2d\u6700\u5927\u7684\u4e00\u7b14\u662f\u901a\u8fc7\u5176\u5b50\u516c\u53f8 Novartis BidCo AG \u5bf9 MorphoSys AG \u53d1\u8d77\u7684\u81ea\u613f\u516c\u5f00\u6536\u8d2d\u8981\u7ea6\uff0c\u91d1\u989d\u9ad8\u8fbe 29.1 \u4ebf\u7f8e\u5143\u3002\u8bfa\u534e\u8fd8\u4ee5\u9ad8\u8fbe 17.5 \u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2d\u4e86 Mariana Oncology \u53ca\u5176\u653e\u5c04\u6027\u836f\u7269\u8d44\u4ea7\u3002\u8fd9\u4e24\u9879\u6536\u8d2d\u5747\u4fa7\u91cd\u4e8e\u80bf\u7624\u5b66\u8d44\u4ea7\u3002<\/p>\n

\u5c3d\u7ba1\u9ed8\u514b\u5728 2022 \u5e74\u548c 2023 \u5e74\u7684\u603b\u4ea4\u6613\u989d\u9886\u5148\uff0c\u4f46\u5728 2024 \u5e74\u8dcc\u81f3\u7b2c\u4e09\u4f4d\uff0c\u5176 30 \u7b14\u4ea4\u6613\u4e2d\u6709 8 \u7b14\u62ab\u9732\u91d1\u989d\uff0c\u652f\u51fa\u9ad8\u8fbe 120.3 \u4ebf\u7f8e\u5143\u3002\u5176\u4e2d\u6700\u6602\u8d35\u7684\u4e00\u7b14\u662f\u627f\u8bfa\u6295\u5165\u9ad8\u8fbe 27 \u4ebf\u7f8e\u5143\uff0c\u7528\u4e8e\u5f15\u8fdb LaNova Medicines Ltd \u7684\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53 1\uff08PD-1\uff09\/\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53cc\u7279\u5f02\u6027\u6297\u4f53 LM-299\uff0c\u65e8\u5728\u5f25\u8865\u5176\u4ea7\u54c1 KEYTRUDA \u5728 2028 \u5e74\u4e13\u5229\u4fdd\u62a4\u5230\u671f\u540e\u5e26\u6765\u7684\u6536\u5165\u635f\u5931\u3002\u968f\u7740\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u80be\u7ec6\u80de\u764c\u7b49\u65e9\u671f\u9002\u5e94\u75c7\u4e2d\u7684\u5e94\u7528\u589e\u52a0\uff0c\u622a\u81f3 2024 \u5e74\u5e95\uff0cKEYTRUDA \u51e0\u4e4e\u5360\u4e86\u9ed8\u514b\u9500\u552e\u989d\u7684\u4e00\u534a\u3002LM-299 \u53ef\u80fd\u6210\u4e3a\u591a\u79cd\u5b9e\u4f53\u7624\u7c7b\u578b\u4e2d\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u9009\u62e9\uff0c\u7279\u522b\u662f\u5bf9\u4e8e PD-1 \u6cbb\u7597\u8010\u836f\u7684\u665a\u671f\u80bf\u7624\u60a3\u8005\u3002<\/p>\n

\u9776\u5411\u86cb\u767d\u8d28\u964d\u89e3\u5242\u7684\u5174\u8d77<\/strong><\/h3>\n

\u5bf9\u201c\u4e0d\u53ef\u6210\u836f\u201d\u9776\u70b9\u7684\u8ffd\u6c42\u6301\u7eed\u63a8\u52a8\u751f\u7269\u5236\u836f\u884c\u4e1a\u7684\u521b\u65b0\uff0c\u5176\u4e2d\u9776\u5411\u86cb\u767d\u8d28\u964d\u89e3\u5242\uff08TPD\uff09\uff0c\u4f8b\u5982\u86cb\u767d\u6c34\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08PROTAC\uff09\u548c\u5206\u5b50\u80f6\u964d\u89e3\u5242\uff0c\u6b63\u5360\u636e\u4e2d\u5fc3\u4f4d\u7f6e\u30022024 \u5e74\uff0c\u8fd9\u4e00\u52bf\u5934\u8f6c\u5316\u4e3a\u4ea4\u6613\u6d3b\u52a8\u7684\u663e\u8457\u6fc0\u589e\u3002\u5ba3\u5e03\u4e86\u8fd120\u7b14\u4ea4\u6613\uff0c\u603b\u989d\u7ea6 132.5 \u4ebf\u7f8e\u5143\uff0c\u6db5\u76d6\u7814\u7a76\u5408\u4f5c\u3001\u65e9\u671f\u8bb8\u53ef\u534f\u8bae\u548c\u5e76\u8d2d\uff08M&A\uff09\u3002\u8bb8\u591a\u6b64\u7c7b\u4ea4\u6613\u7684\u5408\u4f5c\u6027\u8d28\u51f8\u663e\u4e86\u8fd9\u79cd\u6cbb\u7597\u6a21\u5f0f\u5c1a\u5904\u4e8e\u76f8\u5bf9\u65e9\u671f\u7684\u5f00\u53d1\u9636\u6bb5\uff0c\u4ee5\u53ca\u5927\u578b\u5236\u836f\u516c\u53f8\u5bf9\u62a2\u5360\u8fd9\u4e00\u5feb\u901f\u53d1\u5c55\u9886\u57df\u7684\u9886\u5148\u5730\u4f4d\u62b1\u6709\u6d53\u539a\u5174\u8da3\u3002<\/p>\n

\u603b\u90e8\u4f4d\u4e8e\u6ce2\u58eb\u987f\u7684\u751f\u7269\u6280\u672f\u516c\u53f8 Monte Rosa Therapeutics \u8868\u73b0\u7a81\u51fa\uff0c\u5728 2023 \u5e74\u548c 2024 \u5e74\u5747\u8dfb\u8eab\u524d\u4e94\u3002\u7ee7 2023 \u5e74\u672b\u4e0e\u7f57\u6c0f\u5c31\u795e\u7ecf\u5b66\u548c\u80bf\u7624\u5b66\u9776\u70b9\u8fbe\u6210\u4e00\u9879 20.5 \u4ebf\u7f8e\u5143\u5408\u4f5c\u4e0e\u8bb8\u53ef\u534f\u8bae\u4e4b\u540e\uff0c\u8be5\u516c\u53f8\u4e8e 2024 \u5e74\u4e0e\u8bfa\u534e\u5c31\u591a\u4e2a\u9776\u70b9\u8fbe\u6210\u4e86\u4e00\u9879\u4ef7\u503c 22.5 \u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8bb8\u53ef\u534f\u8bae\u3002\u8fd9\u4e24\u9879\u4ea4\u6613\u5747\u4fa7\u91cd\u4e8e\u5229\u7528 Monte Rosa \u4e13\u6709\u7684\u5b9a\u91cf\u548c\u5de5\u7a0b\u5316\u65b0\u751f\u5e95\u7269\u6d88\u9664\uff08QuEEN\u2122\uff09\u53d1\u73b0\u5f15\u64ce\u6240\u53d1\u73b0\u7684\u5206\u5b50\u80f6\u964d\u89e3\u5242\u3002<\/p>\n

\u8f89\u745e\u4e5f\u79ef\u6781\u53c2\u4e0e TPD \u9886\u57df\uff0c\u4e0e TRIANA Biomedicines Inc. \u8fbe\u6210\u4e86\u4e00\u9879\u6f5c\u5728\u4ef7\u503c 15.5 \u4ebf\u7f8e\u5143\u7684\u534f\u8bae\u3002\u8be5\u5408\u4f5c\u5229\u7528 TRIANA Biomedicine Inc. \u4e13\u6709\u7684\u5206\u5b50\u80f6\u53d1\u73b0\u5e73\u53f0\uff0c\u4e13\u6ce8\u4e8e\u53d1\u73b0\u9488\u5bf9\u4e0d\u540c\u75be\u75c5\u9886\u57df\u591a\u4e2a\u9776\u70b9\u7684\u65b0\u578b\u5206\u5b50\u80f6\u964d\u89e3\u5242\u3002\u8f89\u745e\u98ce\u9669\u6295\u8d44\u8fd8\u53c2\u4e0e\u4e86 TRIANA Biomedicines Inc. \u5728 2022 \u5e74\u8fdb\u884c\u7684 1.1 \u4ebf\u7f8e\u5143 A \u8f6e\u878d\u8d44\u3002<\/p>\n

2024 \u5e74\u5176\u4ed6\u9776\u5411\u86cb\u767d\u8d28\u964d\u89e3\u5242\u4ea4\u6613\u4e3b\u8981\u56f4\u7ed5\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u548c\u5fc3\u810f\u4ee3\u8c22\u9776\u70b9\u4ee5\u53ca\u7f55\u89c1\u75c5\u5c55\u5f00\u3002\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684 TPD \u8d44\u4ea7\u8fdb\u5165 1 \u671f\u30011\/2 \u671f\u6216 2 \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9884\u8ba1\u8be5\u9886\u57df\u7684\u52bf\u5934\u5c06\u6301\u7eed\uff0c\u4e3a\u672a\u6765\u7684\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u94fa\u5e73\u9053\u8def\u3002<\/p>\n

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