{"id":435643,"date":"2025-11-17T13:07:03","date_gmt":"2025-11-17T13:07:03","guid":{"rendered":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/?p=435643"},"modified":"2026-03-27T08:28:12","modified_gmt":"2026-03-27T08:28:12","slug":"machine-curation-in-action-a-new-approach-to-essential-tremor-epidemiology","status":"publish","type":"post","link":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/blog\/machine-curation-in-action-a-new-approach-to-essential-tremor-epidemiology\/","title":{"rendered":"AI \u9a71\u52a8\u6570\u636e\u6574\u7406\uff1a\u539f\u53d1\u6027\u9707\u98a4\u6d41\u884c\u75c5\u5b66\u8fce\u6765\u65b0\u65b9\u6cd5"},"content":{"rendered":"

\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u7684\u51fa\u73b0\u5f7b\u5e95\u6539\u53d8\u4e86\u6211\u4eec\u7814\u7a76\u7f55\u89c1\u75c5\u6d41\u884c\u75c5\u5b66\u7684\u65b9\u5f0f\u3002\u901a\u8fc7\u673a\u5668\u5b66\u4e60\uff08ML\uff09\u548c\u6df1\u5ea6\u5b66\u4e60\uff08DL\uff09<\/a>\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u9ad8\u6548\u5730\u7b5b\u9009\u6d77\u91cf\u6587\u732e\uff0c\u4ee5\u63d0\u53d6\u6709\u5173\u6d41\u884c\u75c5\u5b66\u8d8b\u52bf\u548c\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u6570\u636e\u3002\u539f\u53d1\u6027\u9707\u98a4\uff08ET\uff09<\/a>\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u4e0d\u81ea\u4e3b\u7684\u8282\u5f8b\u6027\u9707\u98a4\uff0c\u4e3b\u8981\u5f71\u54cd\u624b\u90e8\uff0c\u4f46\u4e5f\u53ef\u80fd\u7d2f\u53ca\u5934\u90e8\u3001\u58f0\u97f3\u548c\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u3002ET \u7684\u75c5\u7406\u751f\u7406\u5b66\u6d89\u53ca\u5c0f\u8111\u529f\u80fd\u5f02\u5e38\uff0c\u8bb8\u591a\u75c5\u4f8b\u4e2d\u90fd\u6ce8\u610f\u5230\u9057\u4f20\u56e0\u7d20\u548c\u5bb6\u65cf\u6a21\u5f0f\u3002\u8fd9\u79cd\u666e\u904d\u5b58\u5728\u7684\u8fd0\u52a8\u969c\u788d\u5f71\u54cd\u4e86\u7ea6 1% \u7684\u666e\u901a\u4eba\u7fa4\uff0c\u4f46\u5e38\u5e38\u672a\u88ab\u8bca\u65ad<\/a>\u3001\u88ab\u8bef\u8bca<\/a>\u548c\u6cbb\u7597\u4e0d\u8db3<\/a>\uff0c\u7ed9\u804c\u573a\u4eba\u58eb\u5e26\u6765\u4e86\u6311\u6218\u3002<\/p>\n

\u6211\u4eec\u4ee5 ET \u4e3a\u4f8b\uff0c\u8bf4\u660e AI \u5982\u4f55\u6f5c\u5728\u5730\u6539\u53d8\u6211\u4eec\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u7406\u89e3\u548c\u7ba1\u7406\u3002\u672c\u6587\u5c06\u63a2\u8ba8 AI \u5728\u6574\u7406\u548c\u5206\u6790\u75be\u75c5\u6570\u636e\u65b9\u9762\u7684\u591a\u91cd\u76ca\u5904\uff0c\u91cd\u70b9\u4ecb\u7ecd\u8fd9\u4e9b\u6280\u672f\u4e0d\u4ec5\u80fd\u63d0\u9ad8\u51c6\u786e\u6027\u548c\u901f\u5ea6\uff08\u7b2c <\/strong>1 <\/strong>\u8282<\/strong>\uff09\uff0c\u8fd8\u80fd\u8bc6\u522b\u7528\u4e8e\u65e9\u671f\u8bca\u65ad\u7684\u6a21\u5f0f\uff0c\u5e76\u6839\u636e\u60a3\u8005\u7279\u5f81\u8bc4\u4f30\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\uff08\u7b2c <\/strong>2 <\/strong>\u8282<\/strong>\uff09\u3002\u5728\u6211\u4eec\u6df1\u5165\u7814\u7a76 ET \u75c5\u4f8b\u65f6\uff0c\u6211\u4eec\u63ed\u793a\u4e86 AI \u4e3a\u9610\u660e\u8fd9\u79cd\u75be\u75c5\u7684\u590d\u6742\u6027\u6240\u5177\u6709\u7684\u6f5c\u529b\uff0c\u6700\u7ec8\u6709\u52a9\u4e8e\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u5c40\u3002<\/p>\n

\u7528\u4e8e\u7f55\u89c1\u75c5\u6570\u636e\u6574\u7406\u7684\u65b0 <\/strong>AI <\/strong>\u5de5\u5177<\/strong><\/h3>\n

\u636e\u4f30\u8ba1\uff0c\u5168\u7403\u67094\u4ebf\u4eba\u60a3\u6709\u7f55\u89c1\u75c5\u3002\u5728\u79d1\u777f\u552f\u5b89\u6d41\u884c\u75c5\u5b66\u60c5\u62a5<\/a>\u5e73\u53f0\uff0c\u53d1\u75c5\u7387\u548c\u60a3\u75c5\u7387\u6570\u636e\u5e93\uff08Incidence & Prevalence Database \uff0cIPD\uff09\u548c\u6d41\u884c\u75c5\u5b66\u56e2\u961f\u8fdb\u884c\u6709\u9488\u5bf9\u6027\u7684\u6587\u732e\u68c0\u7d22\uff0c\u4ee5\u63d0\u53d6\u8fd9\u4e9b\u7f55\u89c1\u75c5\u7684\u6d41\u884c\u75c5\u5b66\u6570\u636e\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u6211\u4eec\u5df2\u77e5\u7684\u8bb8\u591a\u7f55\u89c1\u75c5\uff0c\u53ef\u7528\u7684\u6570\u636e\u5f88\u5c11\uff0c\u90e8\u5206\u539f\u56e0\u662f\u5f53\u524d\u4eba\u5de5\u6574\u7406\u6d41\u7a0b\u5b58\u5728\u5c40\u9650\u6027\u3002\u4eba\u5de5\u6574\u7406\u5177\u6709\u6311\u6218\u6027\uff0c\u56e0\u4e3a\u8be5\u65b9\u6cd5\u8017\u65f6\u3001\u9700\u8981\u4e13\u4e1a\u77e5\u8bc6\uff0c\u5e76\u4e14\u9700\u8981\u6574\u5408\u6765\u81ea\u533b\u7597\u8bb0\u5f55\u548c\u7814\u7a76\u6587\u7ae0\u7b49\u5404\u79cd\u683c\u5f0f\u7684\u6570\u636e\u3002AI \u53ef\u4ee5\u901a\u8fc7\u63d0\u4f9b\u53ef\u6269\u5c55\u3001\u9ad8\u6548\u548c\u53ef\u9760\u7684\u89e3\u51b3\u65b9\u6848\u6765\u514b\u670d\u8fd9\u4e9b\u6311\u6218\u3002\u8fd9\u4e9b\u5de5\u5177\u53ef\u4ee5\u5feb\u901f\u51c6\u786e\u5730\u8bc6\u522b\u4eba\u5de5\u64cd\u4f5c\u53ef\u80fd\u9519\u8fc7\u7684\u6a21\u5f0f\u548c\u76f8\u5173\u6027\uff0c\u4ece\u800c\u786e\u4fdd\u4e00\u81f4\u6027\u5e76\u52a0\u5feb\u7814\u7a76\u901f\u5ea6\u3002AI \u5de5\u5177\uff0c\u5982\u7ec4\u7ec7\u5b66\u81ea\u76d1\u7763\u56fe\u50cf\u641c\u7d22\uff08SISH<\/a>\uff09\u3001DL \u7b97\u6cd5\u548c ML \u6a21\u578b\uff0c\u53ef\u4ee5\u5206\u6790\u6765\u81ea\u5404\u79cd\u6765\u6e90\u7684\u590d\u6742\u6570\u636e\uff0c\u8bc6\u522b\u6a21\u5f0f\uff0c\u5e76\u63d0\u9ad8\u7f55\u89c1\u75c5\u7684\u8bca\u65ad\u51c6\u786e\u6027\u3002<\/p>\n

W.Z. Kariampuzha\u7b49\u4eba2023 \u5e74\u7684\u4e00\u9879\u7814\u7a76<\/a>\u63d0\u51fa\u4e86 EpiPipeline4RD\uff0c\u8fd9\u662f\u4e00\u4e2a\u4e3a\u81ea\u52a8\u4ece\u7f55\u89c1\u75c5\u6587\u732e\u4e2d\u63d0\u53d6\u6d41\u884c\u75c5\u5b66\u6570\u636e\u800c\u5f00\u53d1\u7684\u6d41\u7a0b\u3002\u8be5\u6d41\u7a0b\u5728\u6d41\u884c\u75c5\u5b66\u6570\u636e\u63d0\u53d6\u65b9\u9762\u8868\u73b0\u51fa\u9ad8\u7cbe\u786e\u7387\u548c\u53ec\u56de\u7387\u5206\u6570\uff0c\u663e\u793a\u51fa\u4e0eOrphanet<\/a>\u7684\u6536\u96c6\u6a21\u578b\u76f8\u5f53\u7684\u7ed3\u679c\u3002\u5176\u76ca\u5904\u662f\u591a\u65b9\u9762\u7684\uff1a\u63d0\u9ad8\u4e86\u75be\u75c5\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u52a0\u5feb\u4e86\u6570\u636e\u5904\u7406\u901f\u5ea6\uff0c\u5e76\u80fd\u591f\u7ba1\u7406\u590d\u6742\u7684\u591a\u7ef4\u6570\u636e\u3002\u8be5\u6d41\u7a0b\u7684\u5f00\u53d1\u7b26\u5408\u8054\u5408\u56fd\u5173\u4e8e\u901a\u8fc7\u51cf\u5c11\u5bf9\u4eba\u5de5\u6d41\u7a0b\u7684\u4f9d\u8d56\u4ee5\u6539\u5584\u7f55\u89c1\u75c5\u6570\u636e\u6536\u96c6\u7684\u51b3\u8bae\u3002\u75c5\u4f8b\u7814\u7a76\u5305\u62ec Rett \u7efc\u5408\u5f81\u3001\u55dc\u9178\u6027\u98df\u7ba1\u708e\u3001\u7ecf\u5178\u578b\u540c\u578b\u534a\u80f1\u6c28\u9178\u5c3f\u75c7\u3001GRACILE \u7efc\u5408\u5f81\u548c\u82ef\u4e19\u916e\u5c3f\u75c7\u3002\u79d1\u777f\u552f\u5b89\u6b63\u5728\u63a2\u7d22\u5c06\u6b64\u5de5\u5177\u53ca\u5176\u4ed6 AI \u89e3\u51b3\u65b9\u6848\u5f15\u5165\u5236\u836f\u884c\u4e1a\uff0c\u4ee5\u63d0\u4f9b\u66f4\u5168\u9762\u3001\u66f4\u51c6\u786e\u7684\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u7ed3\u679c\u548c\u6570\u636e\u3002\u8be5\u6d41\u7a0b\u65e8\u5728\u52a0\u5f3a NIH \u9057\u4f20\u548c\u7f55\u89c1\u75be\u75c5\u4fe1\u606f\u4e2d\u5fc3\uff08Genetic and Rare Diseases Information Center\uff0cGARD<\/a>\uff09\u3002\u672a\u6765\u7684\u53d1\u5c55\u53ef\u80fd\u5305\u62ec\u4e0e\u5176\u4ed6\u73b0\u6709\u7f55\u89c1\u75c5\u6570\u636e\u5e93\u6216\u5e73\u53f0\u5408\u4f5c\u6216\u6574\u5408\uff0c\u4ee5\u589e\u5f3a\u6570\u636e\u7684\u53ef\u53ca\u6027\u548c\u5b9e\u7528\u6027\u3002<\/p>\n

\u65b0\u5e73\u53f0\u80cc\u540e\u7684\u6570\u636e\u79d1\u5b66<\/strong><\/h3>\n

EpiPipeline4RD \u6d41\u7a0b\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\u5305\u62ec\uff1a\u4e00\u4e2a\u65b0\u7684\u7528\u4e8e\u547d\u540d\u5b9e\u4f53\u8bc6\u522b\uff08Named Entity Recognition\uff0cNER\uff09\u7684\u6d41\u884c\u75c5\u5b66\u6570\u636e\u96c6\uff1b\u4e00\u4e2a\u4e3a\u63d0\u53d6\u6d41\u884c\u75c5\u5b66\u6570\u636e\u800c\u5fae\u8c03\u7684 DL \u6846\u67b6\uff08BioBERT\uff09\uff1b\u4ee5\u53ca\u4e00\u4e2a\u7528\u4e8e\u81ea\u52a8\u5316\u63d0\u53d6\u8fc7\u7a0b\u7684 Web \u754c\u9762\u548c Restful API\u3002\u8be5\u6d41\u7a0b\u96c6\u6210\u4e86 ES_Predict\uff0c\u7528\u4e8e\u8bc6\u522b\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u3002\u8be5\u6d41\u7a0b\u4f7f\u7528\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240\uff08European Bioinformatics Institute\uff0cEBI\uff09<\/a>\u548c\u7f8e\u56fd\u56fd\u5bb6\u751f\u7269\u6280\u672f\u4fe1\u606f\u4e2d\u5fc3\uff08National Center for Biotechnology Information\uff0cNCBI\uff09<\/a>\u7684 API \u8fdb\u884c PubMed \u6587\u7ae0\u68c0\u7d22\uff0c\u5e76\u901a\u8fc7\u4e25\u683c\u7b5b\u9009\u673a\u5236\u964d\u4f4e\u5047\u9633\u6027\u7387\u3002\u5b8c\u6574\u7684\u5b9e\u73b0\u3001\u4ee3\u7801\u548c\u8865\u5145\u6570\u636e\u53ef\u5728 GitHub \u4e0a\u83b7\u53d6\uff0c\u5fae\u8c03\u540e\u7684\u6a21\u578b\u548c\u6570\u636e\u96c6\u53ef\u4eceHugging Face\u4e0b\u8f7d<\/a>\u3002<\/p>\n

\u8be5\u6d41\u7a0b\u7684\u771f\u5b9e\u6027\u5982\u4f55\uff1f<\/strong><\/h3>\n

David Lapidus<\/a>\u5728\u8ba8\u8bba\u8fd9\u79cd\u7528\u4e8e\u7f55\u89c1\u75c5\u6d41\u884c\u75c5\u5b66\u7684\u65b0 AI \u5de5\u5177\u7684\u4f18\u52bf\u548c\u5c40\u9650\u6027\u65f6\u6307\u51fa\uff0c\u867d\u7136\u8be5 AI \u5de5\u5177\u901a\u8fc7\u5feb\u901f\u8bc6\u522b\u548c\u603b\u7ed3\u60a3\u75c5\u7387\u7814\u7a76\uff0c\u6bd4 Orphanet \u6709\u4e86\u663e\u8457\u8fdb\u6b65\uff0c\u4f46\u5b83\u4ec5\u5206\u6790 PubMed \u6458\u8981\uff0c\u9519\u8fc7\u4e86\u53ef\u80fd\u5b58\u5728\u4e8e\u6587\u7ae0\u5168\u6587\u4e2d\u7684\u5173\u952e\u4fe1\u606f\uff0c\u4ece\u800c\u5f71\u54cd\u4e86\u6570\u636e\u89e3\u8bfb\u3002\u5728\u5b9e\u8df5\u4e2d\uff0c\u53ef\u80fd\u4f1a\u51fa\u73b0\u4e0d\u4e00\u81f4\u548c\u6570\u636e\u7f3a\u5931\u7684\u60c5\u51b5\uff08\u4f8b\u5982\uff0c\u8be5 AI \u5de5\u5177\u6ca1\u6709\u6536\u5f55 Baujat \u4e8e 2017 \u5e74\u9488\u5bf9\u8fdb\u884c\u6027\u9aa8\u5316\u6027\u7ea4\u7ef4\u53d1\u80b2\u4e0d\u826f [fibrodysplasia ossificans progressive\uff0cFOP]\u7684\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u88ab\u8ba4\u4e3a\u662f\u8be5\u9886\u57df\u7684\u91d1\u6807\u51c6\uff0c\u540c\u65f6\u8fd8\u9057\u6f0f\u4e86\u81ea\u8eab\u514d\u75ab\u6027\u80ba\u6ce1\u86cb\u767d\u6c89\u79ef\u75c7 [autoimmune pulmonary alveolar proteinosis\uff0caPAP]\u7684\u5b9e\u9645\u60a3\u75c5\u7387\u7814\u7a76\uff09\u3002<\/p>\n

\u4e86\u89e3\u539f\u53d1\u6027\u9707\u98a4<\/strong><\/h3>\n

ET <\/a>\u662f\u4e00\u79cd\u666e\u904d\u4f46\u5e38\u88ab\u5ffd\u89c6\u7684\u75be\u75c5\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52a8\u548c\u751f\u6d3b\u8d28\u91cf\uff0c\u4e0d\u540c\u7814\u7a76\u7684\u4f30\u8ba1\u503c\u5404\u4e0d\u76f8\u540c\u3002\u5168\u7403\u7ea6 1% \u7684\u4eba\u53e3\u53d7 ET \u5f71\u54cd\uff0c\u76f8\u5f53\u4e8e 2020 \u5e74\u7ea6\u6709 2,491 \u4e07\u4eba\u3002\u4ec5\u5728\u7f8e\u56fd\uff0cET \u5c31\u5f71\u54cd\u4e86 700 \u4e07\u4eba\uff0c\u5176\u4e2d 100 \u4e07\u4eba\u5728 2015-2019 \u5e74\u671f\u95f4\u786e\u8bca\u5e76\u5bfb\u6c42\u6cbb\u7597\u3002\u6839\u636e\u79d1\u777f\u552f\u5b89\u4e13\u6709\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\uff08RWD\uff09\u8d44\u4ea7\u4f30\u8ba1\uff0c2023 \u5e74\u7f8e\u56fd\u6709\u8d85\u8fc7 41 \u4e07\u4f8b ET \u786e\u8bca\u75c5\u4f8b\u3002<\/p>\n

ET \u7684\u60a3\u75c5\u7387\u968f\u5e74\u9f84\u589e\u957f\u800c\u589e\u52a0\uff0c\u4f30\u8ba1\u503c\u8303\u56f4\u4ece 20 \u5c81\u4ee5\u4e0b\u4eba\u7fa4\u7684 0.04% \u5230 80 \u5c81\u53ca\u4ee5\u4e0a\u4eba\u7fa4\u7684 2.87%\u3002\u79d1\u777f\u552f\u5b89\u7684 IPD \u6570\u636e<\/a>\u8868\u660e\uff0c\u5973\u6027\u3001\u65e0\u5bb6\u65cf\u53f2\u548c\u57fa\u7ebf\u9759\u6b62\u6027\u9707\u98a4\u88ab\u8ba4\u4e3a\u662f\u75be\u75c5\u8fdb\u5c55\u4e0d\u826f\u7684\u9884\u6d4b\u56e0\u7d20<\/a>\u3002<\/p>\n

\u60a3\u8005\u5e38\u4f34\u6709\u5408\u5e76\u75c7\uff0c\u5f71\u54cd\u5176\u5728\u4e13\u4e1a\u73af\u5883\u4e2d\u7684\u6700\u4f73\u8868\u73b0\u80fd\u529b\u3002\u7531\u4e8e ET \u4e0e\u591a\u79cd\u75be\u75c5\u76f8\u5173<\/a>\uff0c\u4e00\u9879\u5bf9\u4e3b\u8981\u5408\u5e76\u75c7\u7684\u8bc4\u4f30\u53d1\u73b0\uff0c\u7ea6 69% \u7684 ET \u75c5\u4f8b\u60a3\u6709\u539f\u53d1\u6027\u9ad8\u8840\u538b\uff0c\u5176\u6b21\u8fd1 50% \u7684 ET \u75c5\u4f8b\u60a3\u6709\u9ad8\u8102\u8840\u75c7\u3002\u5176\u4ed6\u5e38\u89c1\u62a5\u544a\u7684\u5408\u5e76\u75c7\u5305\u62ec\u4e0d\u4f34\u98df\u7ba1\u708e\u7684\u80c3\u98df\u7ba1\u53cd\u6d41\u75c5\uff08GERD\uff09\u30012 \u578b\u7cd6\u5c3f\u75c5\u548c\u7126\u8651\u75c7\u3002<\/p>\n

ML <\/strong>\u8f85\u52a9\u8bca\u65ad<\/strong><\/h3>\n

\u76ee\u524d\uff0cET \u7684\u8bca\u65ad\u57fa\u4e8e\u75c7\u72b6\u548c\u795e\u7ecf\u7cfb\u7edf\u68c0\u67e5\u3002\u7136\u800c\uff0cML \u53ef\u4ee5\u901a\u8fc7\u5206\u6790\u60a3\u8005\u6570\u636e\u6765\u68c0\u6d4b\u53ef\u80fd\u7684 ET \u75c5\u4f8b\uff0c\u4ece\u800c\u5e2e\u52a9\u5f25\u5408\u8bca\u65ad\u4e0a\u7684\u5dee\u8ddd\u3002\u7136\u540e\u53ef\u4ee5\u4f7f\u7528\u6587\u732e\u5bf9\u8fd9\u4e9b\u53ef\u80fd\u7684\u75c5\u4f8b\u8fdb\u884c\u9a8c\u8bc1\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76<\/a>\u4f7f\u7528\u7070\u8d28\u5f62\u6001\u7f51\u7edc\u548c ML \u6a21\u578b\u533a\u5206 ET\u3001\u808c\u5f20\u529b\u969c\u788d\u6027\u9707\u98a4\u548c\u5065\u5eb7\u5bf9\u7167\u7ec4\u3002\u8be5\u7814\u7a76\u53d1\u73b0\uff0c16 \u4e2a\u5f62\u6001\u5173\u7cfb\u7279\u5f81\u548c 1 \u4e2a\u5168\u5c40\u62d3\u6251\u5ea6\u91cf\u53ef\u4ee5\u4f5c\u4e3a\u533a\u5206\u6027\u7279\u5f81\u3002\u56e0\u6b64\uff0c\u7ecf\u8fc7\u8bad\u7ec3\u7528\u4e8e\u5206\u6790\u60a3\u8005\u6570\u636e\u548c\u68c0\u6d4b\u53ef\u80fd ET \u75c5\u4f8b\u7684 ML \u6a21\u578b\u53ef\u4ee5\u6807\u8bb0\u51fa\u9ad8\u5371\u60a3\u8005\uff0c\u4ece\u800c\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u8c03\u67e5\u548c\u6f5c\u5728\u7684\u65e9\u671f\u5e72\u9884\u3002\u4e0a\u8ff0\u65e8\u5728\u68c0\u6d4b\u53ef\u80fd ET \u75c5\u4f8b\u7684 ML \u7814\u7a76\u53d1\u73b0\uff0c\u968f\u673a\u68ee\u6797\u5206\u7c7b\u5668\u5728\u4e09\u5206\u7c7b\u4efb\u52a1\u4e2d\u53d6\u5f97\u4e86\u6700\u4f73\u5206\u7c7b\u6027\u80fd\uff0c\u5e73\u5747\u51c6\u786e\u7387\u8fbe\u5230 78.7%\u3002<\/p>\n

\u53cc\u751f\u5b50\u7814\u7a76\u8868\u660e ET \u53d7\u9057\u4f20\u5f71\u54cd<\/a>\uff0c\u5b58\u5728\u4e0e\u8be5\u75c5\u76f8\u5173\u7684\u6f5c\u5728\u57fa\u56e0\u5ea7\u548c\u57fa\u56e0\u591a\u6001\u6027\u3002\u9057\u4f20\u6613\u611f\u6027\u4e0e\u73af\u5883\u89e6\u53d1\u56e0\u7d20\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4fc3\u8fdb\u4e86 ET \u7684\u53d1\u751f\u548c\u53d1\u5c55\u3002\u8fd9\u79cd\u9057\u4f20\u57fa\u7840\u53ef\u7528\u4e8e ET \u7684\u65e9\u671f\u8bca\u65ad\u3002\u901a\u8fc7\u5206\u6790\u5386\u53f2\u60a3\u8005\u6570\u636e\uff0cML \u6a21\u578b\u53ef\u4ee5\u5b66\u4f1a\u8bc6\u522b\u539f\u53d1\u6027\u9707\u98a4\u7684\u65e9\u671f\u8ff9\u8c61\u3002\u53d1\u8868\u5728 Open Life Sciences<\/a> \u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4f7f\u7528 ML \u7b97\u6cd5\u7b5b\u9009 miRNA\uff0c\u5e76\u786e\u5b9a\u4e86 ET \u53ef\u80fd\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u8be5\u7814\u7a76\u4f7f\u7528\u516c\u5171\u6570\u636e\u96c6\u548c\u4ed6\u4eec\u81ea\u5df1\u7684\u6570\u636e\u96c6\u6765\u7814\u7a76\u8fd9\u79cd\u75be\u75c5\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4e09\u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08APOE\u3001SENP6\u548cZNF148\uff09\u53ef\u4ee5\u6210\u529f\u533a\u5206 ET \u60a3\u8005\u548c\u6b63\u5e38\u5bf9\u7167\u7ec4\u7684\u6837\u672c\u3002<\/p>\n

\u667a\u80fd\u8bbe\u5907\u8f85\u52a9\u7684\u4e25\u91cd\u7a0b\u5ea6\u8bc4\u4f30<\/strong><\/h3>\n

ET \u7684\u4e25\u91cd\u7a0b\u5ea6<\/a>\u4f20\u7edf\u4e0a\u901a\u8fc7\u4e34\u5e8a\u89c2\u5bdf\u548c\u8bc4\u5b9a\u91cf\u8868\u8fdb\u884c\u8bc4\u4f30\uff0c\u91cf\u8868\u5305\u62ec Fahn-Tolosa-Marin \u9707\u98a4\u8bc4\u4f30\u91cf\u8868\uff08FTM-TRS\uff09\u548c\u8fd0\u52a8\u969c\u788d\u5b66\u4f1a\u7533\u529e\u7684\u7edf\u4e00\u5e15\u91d1\u68ee\u75c5\u8bc4\u5b9a\u91cf\u8868\u4fee\u8ba2\u7248\uff08MDS-UPDRS\uff09\u7b2c\u4e09\u90e8\u5206\u3002\u7136\u800c\uff0cML \u53ef\u4ee5\u63d0\u4f9b\u66f4\u5ba2\u89c2\u548c\u5b9a\u91cf\u7684\u8bc4\u4f30\u3002\u51c6\u786e\u7684\u4e34\u5e8a\u8bc4\u4f30\u5de5\u5177\u548c\u667a\u80fd\u624b\u673a\u3001\u667a\u80fd\u624b\u8868\u7b49\u6280\u672f\u53ef\u7528\u4e8e\u9707\u98a4\u6d4b\u91cf\u3002\u53d1\u8868\u5728 BMC Bioinformatics <\/a>\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4f7f\u7528\u7ed1\u5728ET\u60a3\u8005\u624b\u8155\u4e0a\u7684\u667a\u80fd\u624b\u673a\u6536\u96c6\u4f20\u611f\u5668\u6570\u636e\u3002\u7136\u540e\u4f7f\u7528\u6a21\u7cca\u6a21\u578b\u5bf9\u8fd9\u4e9b\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u4e0e\u7ebf\u6027\u6a21\u578b\u76f8\u6bd4\uff0c\u8be5\u6a21\u578b\u5c06\u5e73\u5747\u7edd\u5bf9\u8bef\u5dee\u6307\u6807\u6539\u5584\u4e86 78-81%\uff0c\u4e0e\u57fa\u4e8e\u51b3\u7b56\u6811\u7684\u6a21\u578b\u76f8\u6bd4\uff0c\u6539\u5584\u4e86 71-74%\u3002\u53d1\u8868\u5728 Journal of Neurology <\/a>\u4e0a\u7684\u4e00\u7bc7\u7efc\u5408\u7efc\u8ff0\u8ba8\u8bba\u4e86\u4f7f\u7528\u667a\u80fd\u8bbe\u5907\u8bc4\u4f30ET\u7684\u60c5\u51b5\u3002\u4f7f\u7528\u7684\u8bbe\u5907\u5305\u62ec\u60ef\u6027\u6d4b\u91cf\u5355\u5143\u3001\u808c\u7535\u56fe\u3001\u89c6\u9891\u8bbe\u5907\u548c\u7535\u5b50\u624b\u5199\u677f\u3002\u4f7f\u7528 ML \u6a21\u578b\u5206\u6790\u4ece\u8fd9\u4e9b\u8bbe\u5907\u6536\u96c6\u7684\u6570\u636e\uff0c\u4ee5\u8bc6\u522b ET \u60a3\u8005\u7279\u6709\u7684\u6a21\u5f0f\u548c\u7279\u5f81\u3002<\/p>\n

AI <\/strong>\u5728\u6df1\u5316\u9707\u98a4\u7814\u7a76\u4e2d\u7684\u6f5c\u529b<\/strong><\/h3>\n

\u8fc7\u53bb\u5341\u5e74\u9707\u98a4\u7814\u7a76\u7684\u8fdb\u5c55\u5305\u62ec\u56fd\u9645\u5e15\u91d1\u68ee\u75c5\u4e0e\u8fd0\u52a8\u969c\u788d\u5b66\u4f1a\uff08International Parkinson\u2019s and Movement Disorders Society\uff0cIPMDS\uff09\u5728 2018 \u5e74\u63a8\u51fa\u7684\u65b0\u5206\u7c7b\u7cfb\u7edf<\/a>\u3002\u4e0e\u808c\u5f20\u529b\u969c\u788d\u6027\u9707\u98a4\uff08DT\uff09\u548c\u5e15\u91d1\u68ee\u9707\u98a4\u4e00\u6837\uff0cET \u73b0\u5728\u88ab\u89c6\u4e3a\u4e00\u79cd\u7efc\u5408\u5f81\uff0c\u800c\u4e0d\u662f\u5355\u4e00\u75be\u75c5\u3002ET \u4e0e\u6301\u7eed\u81f3\u5c11 3 \u5e74\u7684\u5b64\u7acb\u6027\u53cc\u4e0a\u80a2\u52a8\u4f5c\u6027\u9707\u98a4\u76f8\u5173\uff0c\u6301\u7eed\u65f6\u95f4\u8f83\u77ed\u7684\u4e3a\u201c\u4e0d\u786e\u5b9a\u6027\u9707\u98a4\u201d\uff0c\u4f34\u6709\u5176\u4ed6\u4f53\u5f81\uff08\u5982\u9759\u6b62\u6027\u9707\u98a4\uff09\u7684 ET \u4e3a\u201cET-plus\u201d\u3002\u8fd9\u79cd\u5206\u7c7b\u610f\u5473\u7740\u4e00\u79cd\u7efc\u5408\u5f81\u53ef\u80fd\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u6f14\u53d8\u6210\u53e6\u4e00\u79cd\u7efc\u5408\u5f81\uff0c\u5c55\u793a\u4e86\u9707\u98a4\u7efc\u5408\u5f81\u7684\u52a8\u6001\u6027\u3002\u9707\u98a4\u7684\u75c5\u7406\u751f\u7406\u5b66\u6d89\u53ca\u5c0f\u8111-\u4e18\u8111-\u76ae\u8d28\u56de\u8def\uff0c\u4e0d\u540c\u7c7b\u578b\u7684\u9707\u98a4\u53ef\u80fd\u4e0e\u4e0d\u540c\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\u6709\u5173\u3002<\/p>\n

\u5c06 AI \u6574\u5408\u5230 ET \u7684\u5e02\u573a\u5206\u6790\u4e2d\u5df2\u663e\u793a\u51fa\u5de8\u5927\u6f5c\u529b\u3002\u4f20\u611f\u5668\u4ee5\u53ca\u667a\u80fd\u624b\u673a\u548c\u667a\u80fd\u624b\u8868\u7b49\u6280\u672f\u6b63\u88ab\u7528\u4e8e\u9707\u98a4\u6d4b\u91cf\uff0c\u63d0\u9ad8\u4e86\u9707\u98a4\u8bc4\u4f30\u7684\u7cbe\u786e\u5ea6\u3002AI \u80fd\u591f\u5feb\u901f\u51c6\u786e\u5730\u5904\u7406\u6d77\u91cf\u6570\u636e\uff0c\u5e76\u8bc6\u522b\u51fa\u4f20\u7edf\u5206\u6790\u65b9\u6cd5\u53ef\u80fd\u5ffd\u7565\u7684\u6a21\u5f0f\u548c\u8d8b\u52bf\uff0c\u4ece\u800c\u80fd\u591f\u5bf9\u5e02\u573a\u683c\u5c40\u6709\u66f4\u7ec6\u81f4\u7684\u7406\u89e3\u3002\u7136\u800c\uff0cAI \u5728\u7f55\u89c1\u75c5\u9886\u57df\u7684\u5e94\u7528\u4e5f\u5b58\u5728\u7f3a\u70b9\u3002\u9274\u4e8e\u8fd9\u4e9b\u75be\u75c5\u7684\u7f55\u89c1\u6027\uff0c\u6709\u6548\u8fd0\u884c\u6240\u9700\u7684\u5927\u91cf\u9ad8\u8d28\u91cf\u6570\u636e\u96c6\u53ef\u80fd\u662f\u4e00\u4e2a\u6311\u6218\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u5de5\u5177\u7684\u590d\u6742\u6027\u53ef\u80fd\u4f7f\u5176\u5728\u6ca1\u6709\u4e13\u4e1a\u77e5\u8bc6\u7684\u60c5\u51b5\u4e0b\u96be\u4ee5\u4f7f\u7528\u548c\u89e3\u8bfb\u3002\u6700\u540e\uff0c\u56f4\u7ed5\u6570\u636e\u9690\u79c1\u548c\u654f\u611f\u5065\u5eb7\u4fe1\u606f\u7684\u6f5c\u5728\u6ee5\u7528\u4e5f\u5f15\u53d1\u4e86\u4f26\u7406\u65b9\u9762\u7684\u8003\u91cf\u3002\u5c3d\u7ba1\u5b58\u5728\u8fd9\u4e9b\u6311\u6218\uff0cAI \u5728\u75be\u75c5\u6d41\u884c\u75c5\u5b66\u9886\u57df\u7684\u6f5c\u529b\u662f\u4e0d\u53ef\u5426\u8ba4\u7684\uff0c\u5e76\u7ee7\u7eed\u63a8\u52a8\u8be5\u9886\u57df\u7684\u8fdb\u6b65\u3002<\/p>\n

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