{"id":435647,"date":"2025-10-07T14:22:01","date_gmt":"2025-10-07T14:22:01","guid":{"rendered":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/?p=435647"},"modified":"2026-04-16T06:56:11","modified_gmt":"2026-04-16T06:56:11","slug":"six-companies-enabling-precision-interventions-for-undruggable-targets","status":"publish","type":"post","link":"https:\/\/www.clarivate.com.cn\/life-sciences-healthcare\/blog\/six-companies-enabling-precision-interventions-for-undruggable-targets\/","title":{"rendered":"\u516d\u5bb6\u516c\u53f8\u4e3a\u201c\u4e0d\u53ef\u6210\u836f\u201d\u9776\u70b9\u5b9e\u73b0\u7cbe\u51c6\u5e72\u9884"},"content":{"rendered":"<p>\u86cb\u767d\u8d28\u964d\u89e3\u5242\u5df2\u6210\u4e3a\u5236\u836f\u9886\u57df\u7684\u4e00\u5927\u7126\u70b9\uff0c\u56e0\u5176\u6709\u671b\u653b\u514b\u4f20\u7edf\u6cbb\u7597\u624b\u6bb5\u96be\u4ee5\u5e94\u5bf9\u7684\u75be\u75c5\uff0c\u5305\u62ec\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u708e\u75c7\u6027\u75be\u75c5\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53ca\u611f\u67d3\u6027\u75be\u75c5\u7b49\u3002\u5bf9\u86cb\u767d\u964d\u89e3\u5242\u4f5c\u7528\u673a\u5236\u7684\u7406\u89e3\u53d6\u5f97\u7a81\u7834\uff0c\u4ee5\u53ca\u86cb\u767d\u6c34\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08proteolysis-targeting 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\u548c\u5206\u5b50\u80f6\u964d\u89e3\u5242\u7684\u5f00\u53d1\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u4f46\u5728\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u9884\u6d4b\u6027\u3001\u7ec6\u80de\u6e17\u900f\u6027\u548c\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u7b49\u65b9\u9762\u4ecd\u7136\u5b58\u5728\u6311\u6218\u3002\u8ba1\u7b97\u5efa\u6a21\u548c\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u7684\u8fdb\u6b65\u6b63\u5728\u901a\u8fc7\u7b80\u5316\u53d1\u73b0\u548c\u4f18\u5316\u8fc7\u7a0b\u6765\u5e2e\u52a9\u514b\u670d\u8fd9\u4e9b\u969c\u788d\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6676\u6cf0\u79d1\u6280\uff08XtalPi\uff09\u4e0eDoveTree Medicines \u4e4b\u95f4\u4e00\u9879\u4ef7\u503c 60 \u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\uff0c\u5145\u5206\u4f53\u73b0\u4e86 AI \u9a71\u52a8\u7684\u836f\u7269\u53d1\u73b0\u5982\u4f55\u52a0\u901f\u86cb\u767d\u964d\u89e3\u5242\u5728\u80bf\u7624\u3001\u514d\u75ab\u3001\u795e\u7ecf\u548c\u4ee3\u8c22\u75be\u75c5\u9886\u57df\u7684\u5f00\u53d1\u3002\u8fd9\u4e9b\u521b\u65b0\u51f8\u663e\u4e86\u6280\u672f\u5982\u4f55\u5851\u9020\u8be5\u9886\u57df\u7684\u672a\u6765\u3002<\/p>\n<p>\u9ad8\u4ef7\u503c\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u7684\u6fc0\u589e\u4e5f\u53cd\u6620\u4e86\u8fd9\u4e00\u589e\u957f\u52bf\u5934\u3002\u4f8b\u5982\uff0cMonte Rosa Therapeutics \u4e0e\u8bfa\u534e\uff08Novartis\uff09\u5728\u5206\u5b50\u80f6\u964d\u89e3\u5242\u9886\u57df\u8fbe\u6210\u7684 57 \u4ebf\u7f8e\u5143\u5408\u4f5c\uff0c\u663e\u793a\u4e86\u5927\u578b\u5236\u836f\u516c\u53f8\u5bf9\u65b0\u7597\u6cd5\u7684\u9ad8\u5ea6\u5173\u6ce8\u548c\u6295\u8d44\u70ed\u60c5\u3002\u4ec5\u57282024 \u5e74\uff0c\u5c31\u5ba3\u5e03\u4e86\u8fd1 20 \u7b14\u4ea4\u6613\uff0c\u603b\u989d\u8d85\u8fc7 130 \u4ebf\u7f8e\u5143\uff0c\u51f8\u663e\u4e86\u8fd9\u4e2a\u8fc5\u901f\u6269\u5f20\u9886\u57df\u7684\u7ade\u4e89\u6001\u52bf\u4e0e\u5408\u4f5c\u8d8b\u52bf\u3002\u8fd9\u4e9b\u5408\u4f5c\u5927\u591a\u7531\u65b0\u8fd1\u6210\u7acb\u7684\u5c0f\u578b\u751f\u7269\u6280\u672f\u516c\u53f8\u63a8\u52a8\uff0c\u5b83\u4eec\u6b63\u81f4\u529b\u4e8e\u5efa\u7acb\u4e13\u6709\u7684\u53d1\u73b0\u5e73\u53f0\uff0c\u5e76\u5438\u5f15\u5e0c\u671b\u5b9e\u73b0\u7ba1\u7ebf\u591a\u6837\u5316\u7684\u5927\u578b\u5236\u836f\u516c\u53f8\u4e0e\u4e4b\u5408\u4f5c\u3002<\/p>\n<p>\u5728\u4e34\u5e8a\u5c42\u9762\uff0c\u86cb\u767d\u964d\u89e3\u5242\u9886\u57df\u6b63\u8fc8\u5411\u5173\u952e\u6027\u91cc\u7a0b\u7891\u3002Arvinas \u548c\u8f89\u745e\uff08Pfizer\uff09\u4e3a Vepdegestrant\uff08ARV-471\uff09\u63d0\u4ea4\u7684\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c\u7684\u65b0\u836f\u7533\u8bf7\uff0c\u6807\u5fd7\u7740\u8be5\u7c7b\u836f\u7269\u5728\u76d1\u7ba1\u5ba1\u8bc4\u4e2d\u53d6\u5f97\u4e86\u8fc4\u4eca\u4e3a\u6b62\u7684\u6700\u5927\u8fdb\u5c55\uff0c\u800c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08Bristol Myers Squibb\uff09\u548c\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u6b63\u5728\u5c06 PROTAC \u63a8\u8fdb\u81f3 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u80bf\u7624\u5b66\u4e4b\u5916\uff0c\u521b\u65b0\u6b63\u6269\u5c55\u5230\u975e\u80bf\u7624\u75be\u75c5\uff0c\u4f8b\u5982\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff0c\u5f00\u62d3\u836f\u4e1a\uff08Kintor Pharmaceutical\uff09\u62a5\u544a\u4e86\u79ef\u6781\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002\u968f\u7740\u66f4\u591a\u4e34\u5e8a\u8bc1\u636e\u7684\u51fa\u73b0\uff0c\u86cb\u767d\u964d\u89e3\u5242\u6709\u671b\u4ece\u5b9e\u9a8c\u6027\u7597\u6cd5\u8fc7\u6e21\u5230\u4e3b\u6d41\u7cbe\u51c6\u533b\u7597\uff0c\u5e76\u6709\u6f5c\u529b\u91cd\u5851\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u683c\u5c40\u3002<\/p>\n<p>\u7531\u4e8e\u4f17\u591a\u516c\u53f8\u81f4\u529b\u4e8e\u63a2\u7d22\u4e0d\u540c\u7684\u7814\u53d1\u8def\u5f84\u548c\u9776\u70b9\uff0c\u4e14\u901a\u5e38\u5904\u4e8e\u975e\u5e38\u65e9\u671f\u7684\u9636\u6bb5\uff0c\u8981\u53ca\u65f6\u4e86\u89e3\u5b83\u4eec\u65e5\u76ca\u589e\u591a\u7684\u6d3b\u52a8\uff0c\u4ee5\u53ca\u80cc\u540e\u5e9e\u5927\u7684\u6295\u8d44\u8005\u3001\u5408\u4f5c\u4f19\u4f34\u548c\u7814\u7a76\u4e2d\u5fc3\u751f\u6001\u7cfb\u7edf\uff0c\u53ef\u80fd\u5177\u6709\u6311\u6218\u6027\u3002\u4e3a\u4e86\u66f4\u6df1\u5165\u4e86\u89e3\u8be5\u9886\u57df\u5e76\u8bc6\u522b\u5177\u6709\u6f5c\u529b\u7684\u521b\u65b0\u8005\uff0c\u79d1\u777f\u552f\u5b89\u7684\u5206\u6790\u5e08\u8bc4\u4f30\u4e86\u8be5\u9886\u57df\u7684\u4ea4\u6613\u4f30\u503c\u3001\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e13\u5229\u548c\u5e02\u573a\u6279\u51c6\u6570\u636e\uff0c\u6700\u7ec8\u8bc4\u9009\u51fa\u516d\u5bb6\u503c\u5f97\u5173\u6ce8\u7684\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u516c\u53f8\uff1a<\/p>\n<ul>\n<li><strong>Beactica Therapeutics AB<\/strong>\uff0c\u8be5\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u745e\u5178 Uppsala\uff0c\u6b63\u5728\u901a\u8fc7\u5176 Eclipsor\u2122 \u5e73\u53f0\u5f00\u53d1\u65b0\u578b\u5c0f\u5206\u5b50\u7597\u6cd5\uff0c\u4ee5\u63a8\u8fdb\u53d8\u6784\u8c03\u8282\u5242\u548c\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u75be\u75c5\u3002<\/li>\n<li><strong>Kymera Therapeutics<\/strong>\uff0c\u8be5\u516c\u53f8\u662f\u4e00\u5bb6\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u6c83\u7279\u6566\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u6b63\u5728\u5f00\u53d1\u53e3\u670d\u5c0f\u5206\u5b50\u86cb\u767d\u964d\u89e3\u5242\uff0c\u4e13\u6ce8\u4e8e\u63a8\u8fdb\u514d\u75ab\u5b66\u9886\u57df\u7684\u53d8\u9769\u6027\u7597\u6cd5\uff0c\u5176\u4e2d\u5305\u62ec\u9996\u4e2a\u8fdb\u5165\u514d\u75ab\u75be\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u964d\u89e3\u5242\u3002<\/li>\n<li><strong>Monte Rosa Therapeutics<\/strong>\uff0c\u8be5\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\uff0c\u5728\u745e\u58eb\u5df4\u585e\u5c14\u8bbe\u6709\u8fd0\u8425\u673a\u6784\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u5176 AI \u9a71\u52a8\u7684 QuEEN\u2122 \u53d1\u73b0\u5f15\u64ce\uff0c\u63a8\u8fdb\u201c\u540c\u7c7b\u552f\u4e00\u201d\uff08only-in-class\uff09\u7684\u5206\u5b50\u80f6\u964d\u89e3\u5242\u4e34\u5e8a\u7ba1\u7ebf\uff0c\u521d\u6b65\u7528\u4e8e\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u548c\u80bf\u7624\u75be\u75c5\u3002<\/li>\n<li><strong>Nurix Therapeutics Inc<\/strong>\uff0c\u8be5\u516c\u53f8\u4f4d\u4e8e\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5e03\u91cc\u65af\u73ed\uff0c\u6b63\u5728\u5229\u7528\u5176 DEL-AI \u5f15\u64ce\u63a8\u8fdb\u591a\u5143\u5316\u7684\u5408\u4f5c\u7ba1\u7ebf\uff0c\u5305\u62ec\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u708e\u75c7\u75be\u75c5\u7684\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u548c\u964d\u89e3\u5242-\u6297\u4f53\u5076\u8054\u7269\uff08degrader-antibody conjugate\uff0cDAC\uff09\u3002<\/li>\n<li><strong>TRIANA Biomedicines<\/strong>\uff0c\u8be5\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u5217\u514b\u661f\u6566\uff0c\u5176\u5e73\u53f0\u80fd\u591f\u8bc4\u4f30\u8d85\u8fc7 600 \u79cd E3 \u6cdb\u7d20\u8fde\u63a5\u9176\u53ca\u5176\u75be\u75c5\u76f8\u5173\u9776\u70b9\u5e76\u8fdb\u884c\u4f18\u5148\u6392\u5e8f\uff0c\u4ee5\u7528\u4e8e\u5f00\u53d1\u5206\u5b50\u80f6\u964d\u89e3\u5242\u3002<\/li>\n<li><strong>TRIMTECH Therapeutics<\/strong>\uff0c\u8be5\u516c\u53f8\u4f4d\u4e8e\u82f1\u56fd\u5251\u6865\uff0c\u6b63\u5728\u5f00\u53d1\u5176\u4e13\u6709\u7684 TRIMTAC<sup>\u00ae <\/sup>\u548c TRIMGLUE<sup>\u00ae <\/sup>\u5c0f\u5206\u5b50\u964d\u89e3\u5242\uff0c\u65e8\u5728\u62db\u52df TRIM21\uff0c\u901a\u8fc7\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\u8fdb\u884c\u805a\u96c6\u4f53\u9009\u62e9\u6027\u964d\u89e3\uff0c\u4ee5\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u708e\u75c7\u75be\u75c5\u3002<\/li>\n<\/ul>\n<h3>\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u5e02\u573a\u6b63\u5728\u8fc5\u901f\u6269\u5f20\uff0c\u5177\u4f53\u4f53\u73b0\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a<\/h3>\n<ul>\n<li>\u6839\u636e\u79d1\u777f\u552f\u5b89\u7684\u6570\u636e\uff0c<strong>\u8fc7\u53bb\u4e94\u5e74\u4e2d\u4ea4\u6613\u603b\u989d\u548c\u6570\u91cf\u5747\u6709\u6240\u589e\u52a0<\/strong>\uff0c\u56e0\u4e3a\u5236\u836f\u516c\u53f8\u8ba4\u8bc6\u5230\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u6539\u53d8\u6cbb\u7597\u6a21\u5f0f\u7684\u6f5c\u529b\uff0c\u5e76\u79ef\u6781\u5c06\u8be5\u6cbb\u7597\u6a21\u5f0f\u7eb3\u5165\u5176\u7ba1\u7ebf\u4e2d\uff1b<\/li>\n<li><strong>\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u4e0d\u65ad\u589e\u52a0<\/strong>\uff0c\u968f\u7740\u65b0\u516c\u53f8\u8fdb\u5165\u8be5\u9886\u57df\uff0c\u4e3a\u5176\u4ed6\u9776\u70b9\u63d0\u4f9b\u8bc1\u636e\uff0c\u5e76\u514b\u670d\u73b0\u6709\u65b9\u6cd5\u7684\u6311\u6218\u3002<\/li>\n<li><strong>\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u7684\u76d1\u7ba1\u73af\u5883\u65e5\u8d8b\u6210\u719f<\/strong>\uff0c\u968f\u7740\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u9010\u6b65\u8fdb\u5165\u540e\u671f\u5f00\u53d1\u9636\u6bb5\uff0c\u76d1\u7ba1\u673a\u6784\u5728\u5ba1\u67e5\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u65b9\u9762\u79ef\u7d2f\u4e86\u66f4\u591a\u7ecf\u9a8c\uff0c\u4e3a\u8be5\u7c7b\u7597\u6cd5\u7684\u5ba1\u6279\u548c\u4e0a\u5e02\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/li>\n<\/ul>\n<p><strong>\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u8fd9\u4e00\u6fc0\u52a8\u4eba\u5fc3\u7684\u6cbb\u7597\u9886\u57df\u7684\u4fe1\u606f\uff0c\u5e76\u6df1\u5165\u4e86\u89e3\u6211\u4eec\u5173\u6ce8\u7684\u516d\u5bb6\u516c\u53f8\uff0c\u8bf7\u4e0b\u8f7d\u62a5\u544a\u300a<\/strong><a href=\"https:\/\/discover.clarivate.com\/CTW_Protein_Degraders_2025_CN\" target=\"_blank\" 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